CHRONIC KIDNEY DISEASE\u00a0has been\u00a0associated with greater post-stroke cognitive decline, according to new evidence from\u00a0Seoul, Republic of\u00a0Korea.\u00a0<\/p>\n
The findings come from a retrospective\u00a0population-based\u00a0study of 359,572 individuals who underwent repeated standardised cognitive assessments.\u00a0\u00a0<\/p>\n
Researchers examined\u00a0data\u00a0from the Korean National Health Insurance Service and Long-Term Care Insurance databases.\u00a0Changes in cognitive function\u00a0were evaluated\u00a0using repeated cognitive function equivalent score assessments.\u00a0\u00a0<\/p>\n
Participants were categorised according to\u00a0chronic kidney disease<\/a>\u00a0(CKD)\u00a0status and stroke timing, allowing investigators to assess whether kidney disease\u00a0significantly\u00a0affected\u00a0the trajectory of cognitive decline after\u00a0stroke<\/a>.\u00a0\u00a0<\/p>\n Stroke Survivors\u00a0with\u00a0CKD\u00a0Face Faster Cognitive Decline\u00a0<\/p>\n CKD\u00a0alone was associated with a\u00a0moderately\u00a0faster rate of cognitive decline compared with individuals without\u00a0CKD\u00a0or stroke.\u00a0<\/p>\n Pre-existing\u00a0stroke alone was not significantly associated with accelerated decline, but when\u00a0CKD\u00a0co-existed with\u00a0pre-existing\u00a0stroke, the association increased substantially.\u00a0<\/p>\n Incident stroke was also linked to faster deterioration in cognitive function.\u00a0The effect was numerically greater among individuals with both chronic kidney disease and incident stroke.\u00a0\u00a0<\/p>\n The largest effect size was\u00a0observed\u00a0in participants with recurrent stroke and\u00a0CKD.\u00a0<\/p>\n Evidence of a Stroke-Specific Effect\u00a0<\/p>\n A significant positive interaction was\u00a0identified\u00a0between\u00a0CKD\u00a0and\u00a0pre-existing\u00a0stroke on the continuous cognitive outcome scale.\u00a0\u00a0<\/p>\n Interactions involving incident and recurrent stroke showed similar directional trends but did not achieve statistical significance.\u00a0\u00a0<\/p>\n When clinically significant cognitive decline was assessed, the combination of\u00a0CKD\u00a0and incident stroke produced the highest risk, exceeding the risk associated with incident stroke alone.\u00a0<\/p>\n Findings Not Replicated in Neurodegenerative Disease\u00a0<\/p>\n Secondary analyses explored whether\u00a0CKD\u00a0similarly amplified cognitive decline in dementia and Parkinson\u2019s disease.\u00a0\u00a0<\/p>\n No consistent acceleration of cognitive decline was\u00a0observed\u00a0when\u00a0CKD\u00a0co-occurred with these neurodegenerative conditions.\u00a0<\/p>\n Interaction estimates were either null or negative, suggesting the observed association may be more specific to vascular disease processes than to neurodegeneration.\u00a0\u00a0<\/p>\n While evidence for interaction varied across analytical approaches, the findings\u00a0indicate\u00a0that individuals with\u00a0CKD\u00a0who experience stroke may\u00a0represent\u00a0a population at increased risk of accelerated cognitive deterioration and may\u00a0warrant\u00a0closer cognitive monitoring.\u00a0\u00a0<\/p>\n Reference\u00a0<\/p>\n Kim HJ\u00a0et al.\u00a0Chronic kidney disease\u00a0is associated with greater post-stroke cognitive decline in a nationwide longitudinal cohort. Sci Rep.\u00a02026;DOI:10.1038\/s41598-026-60509-7\u00a0<\/p>\n Featured\u00a0image:\u00a0Pavel Danllyuk\u00a0on\u00a0Pexels\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"CHRONIC KIDNEY DISEASE\u00a0has been\u00a0associated with greater post-stroke cognitive decline, according to new evidence from\u00a0Seoul, Republic of\u00a0Korea.\u00a0 The findings…\n","protected":false},"author":2,"featured_media":556002,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-556001","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/556001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=556001"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/556001\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/556002"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=556001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=556001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=556001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}