{"id":556113,"date":"2026-07-18T13:52:08","date_gmt":"2026-07-18T13:52:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/556113\/"},"modified":"2026-07-18T13:52:08","modified_gmt":"2026-07-18T13:52:08","slug":"psc-uc-shares-mast-cell-state-with-uc","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/556113\/","title":{"rendered":"PSC-UC Shares Mast Cell State with UC"},"content":{"rendered":"<p><a href=\"https:\/\/www.emjreviews.com\/hepatology\/article\/primary-sclerosing-cholangitis-a-clinical-update\/\" rel=\"nofollow noopener\" target=\"_blank\">PRIMARY\u00a0sclerosing cholangitis<\/a>\u00a0(PSC) and ulcerative colitis (UC)\u00a0exhibit\u00a0distinct colonic mucosa\u00a0topography but share similar cell\u00a0programmes during active disease, providing insights that could help guide tailored clinical management, according to a new study.\u00a0<\/p>\n<p>PSC-UC\u00a0<\/p>\n<p>PSC\u00a0is a chronic, progressing cholestatic disease that\u00a0frequently\u00a0co-occurs with inflammatory bowel disease\u00a0(PSC-IBD).\u00a0<\/p>\n<p>When PSC affects the colon, it is referred to as PSC-ulcerative colitis (PSC-UC). Although PSC-UC resembles conventional UC, it is characterised by less severe disease flares, right-sided colonic predominance, and a greater lifetime risk of colorectal cancer than UC alone.\u00a0<\/p>\n<p>The aim of this study was to\u00a0reveal the differences in the fundamental biology between PSC-UC and UC.\u00a0<\/p>\n<p>Distinct\u00a0Mucosa Topography\u00a0in\u00a0PSC-UC\u00a0<\/p>\n<p>Researchers\u00a0combined\u00a0single-cell mRNA and antigen receptor sequencing, 16S ribosomal RNA gene analysis and spatial transcriptomics on biopsies from four colon regions of patients with PSC-UC and UC during endoscopic remission\u00a0or at the time of relapse.\u00a0<\/p>\n<p>Results\u00a0indicated\u00a0that\u00a0the PSC-UC colon\u00a0harboured\u00a0distinct\u00a0mucosal-adherent\u00a0microbial\u00a0communities\u00a0when compared\u00a0to\u00a0healthy controls\u00a0and the\u00a0UC colon. These mucosal-adherent\u00a0communities\u00a0were\u00a0also\u00a0region-specific.\u00a0<\/p>\n<p>Interestingly,\u00a0the researchers also\u00a0identified\u00a0an\u00a0enrichment\u00a0of activated\u202fCD8 T\u00a0cells\u00a0and\u00a0\u03b3\u03b4\u00a0T cells at the right colon,\u00a0even in\u00a0the\u00a0absence of\u00a0histological inflammation.\u00a0<\/p>\n<p>Mast Cell Population\u00a0<\/p>\n<p>Contrastingly, a\u00a0potentially pro-tumourigenic\u202fTMEM176B+\u202fmast cell population\u00a0was\u00a0enriched in the colon during disease relapse in both PSC-UC and UC.\u00a0<\/p>\n<p>The findings suggest that despite fundamental biological differences between the two conditions, they share similar cell programmes during active disease, including this mast cell state.\u00a0<\/p>\n<p>Conclusion\u00a0<\/p>\n<p>The study\u00a0demonstrates\u00a0that PSC-UC and UC are biologically distinct diseases with distinct colonic mucosal topographies, despite sharing common immune cell programmes during active disease. According to the authors, these findings provide\u00a0insights that may help inform more tailored clinical management and the development of precision therapies for patients with PSC-UC.\u00a0<\/p>\n<p>Reference\u00a0\u00a0<\/p>\n<p>Tearle\u00a0JL\u202fet al.\u202fPrimary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.\u202fNat Commun.\u202f2026;DOI:10.1038\/s41467-026-75231-1.\u00a0<\/p>\n<p>Featured Image:\u00a0fizkes\u00a0on Adobe Stock.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"PRIMARY\u00a0sclerosing cholangitis\u00a0(PSC) and ulcerative colitis (UC)\u00a0exhibit\u00a0distinct colonic mucosa\u00a0topography but share similar cell\u00a0programmes during active disease, providing insights that&hellip;\n","protected":false},"author":2,"featured_media":556114,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-556113","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/556113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=556113"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/556113\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/556114"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=556113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=556113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=556113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}