{"id":557223,"date":"2026-07-19T09:15:10","date_gmt":"2026-07-19T09:15:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/557223\/"},"modified":"2026-07-19T09:15:10","modified_gmt":"2026-07-19T09:15:10","slug":"breast-cancer-mri-shows-high-subtype-accuracy","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/557223\/","title":{"rendered":"Breast Cancer MRI Shows High Subtype Accuracy"},"content":{"rendered":"<p>MULTIPARAMETRIC MRI could help distinguish between luminal and non-luminal invasive ductal carcinoma (IDC), the most common type of <a href=\"https:\/\/www.emjreviews.com\/oncology\/video\/advancing-care-in-er-her2-esr1m-mbc\/\" rel=\"nofollow noopener\" target=\"_blank\">breast cancer<\/a>, with high accuracy, according to a prospective study, offering clinicians a potential non-invasive adjunct to histopathology when planning personalised treatment.<\/p>\n<p>The study found that combining specific MRI features achieved an area under the curve (AUC) of 0.92 for differentiating luminal and non-luminal tumours, with 87% sensitivity and 86% specificity. The findings suggest multiparametric MRI may provide clinically useful imaging biomarkers, although external validation is needed before routine implementation.<\/p>\n<p>A Potential MRI Biomarker in Breast Cancer Assessment<\/p>\n<p>Researchers evaluated whether multiparametric breast MRI could non-invasively distinguish luminal (A and B) from non-luminal (HER2-enriched and triple-negative) IDC subtypes.<\/p>\n<p>The prospective single-centre study included 102 patients with newly diagnosed IDC who underwent 3T multiparametric MRI before treatment. Tumours were classified according to immunohistochemistry. MRI protocols included T1-weighted imaging, T2-weighted imaging, subtraction imaging, dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted imaging (DWI), and MR spectroscopy (MRS). Investigators assessed morphological characteristics alongside semiquantitative and quantitative DCE-MRI parameters, apparent diffusion coefficient (ADC) values, and MRS choline peaks.<\/p>\n<p>Distinct Imaging Features Linked to Non-Luminal Disease<\/p>\n<p>Among the 102 patients, 48 (47.1%) had luminal tumours and 54 (52.9%) had non-luminal disease.<\/p>\n<p>Luminal tumours were more likely to appear irregular with spiculated margins and heterogeneous enhancement. In contrast, non-luminal tumours more frequently demonstrated circumscribed margins, rim enhancement, perilesional oedema and axillary lymphadenopathy.<\/p>\n<p>Non-luminal cancers also showed higher Ktrans values, signal enhancement ratio (SER) and maximum slope of increase, alongside lower extracellular extravascular volume fraction (Ve) and ADC values. A choline peak on MR spectroscopy was observed more frequently in the non-luminal group.<\/p>\n<p>Multivariable regression identified perilesional oedema, low Ve and high SER as independent predictors of non-luminal breast cancer. When combined, these parameters achieved an AUC of 0.92, with 87% sensitivity and 86% specificity.<\/p>\n<p>Adjunctive Role Requires Further Validation<\/p>\n<p>The findings support multiparametric MRI as a reliable adjunct to histopathology for differentiating breast cancer subtypes and may help inform personalised treatment strategies and prognostication. However, as the study was conducted at a single centre with 102 patients, the authors noted that external validation is required before these imaging markers can be adopted in routine clinical practice.<\/p>\n<p>Reference<\/p>\n<p>Mohakud S et al. Evaluating the utility of qualitative and quantitative multiparametric MRI parameters in distinguishing luminal and non-luminal breast cancer subtypes. Clin Radiol. 2026;DOI:10.1016\/j.crad.2026.107426.<\/p>\n<p>Featured image: David A Litman on Adobe Stock<\/p>\n","protected":false},"excerpt":{"rendered":"MULTIPARAMETRIC MRI could help distinguish between luminal and non-luminal invasive ductal carcinoma (IDC), the most common type of&hellip;\n","protected":false},"author":2,"featured_media":557224,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-557223","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/557223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=557223"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/557223\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/557224"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=557223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=557223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=557223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}