Dr. Le Roux: So the most important thing of, you know, understanding from the SYNCHRONIZE studies is that the objective is becoming health gain, not only weight loss. Weight loss is part of the outcomes when we treat the disease of obesity, but what we focused on are, you know, what are the health gains that we\u2019ve had? And what we see is substantial metabolic health gains, especially when it comes to the liver and reducing liver fat, but also with the view in future of reducing liver fibrosis.<\/p>\n
Can you elaborate a little on what the results tell us about survodutide\u2019s unique dual glucagon\/GLP-1 mechanism?<\/p>\n
Dr. Le Roux: Yeah, because survodutide acts like an oxyntomodulin analog, a natural gut hormone that comes from the endocrine L cells in the gut, it binds both the GLP-1 receptor and the glucagon receptor. And what we see is when it does this in the brain, we see substantial weight loss, so that controls the disease of obesity.<\/p>\n
But we also see potential weight loss-independent benefits, and we\u2019ve known from GLP-1 when it binds the GLP-1 receptor in the pancreas, we get the incretin response, and that\u2019s weight loss-independent. We also see the other benefits from GLP-1. For example, when it binds the receptors and smooth muscle in vasculature, we get improvements in blood pressure. That\u2019s weight loss-independent. But what we are now seeing is when you bind the glucagon receptor in the liver, you see reductions in liver fat that goes beyond what you can expect from the weight loss.<\/p>\n
So we see substantial weight loss for the disease of obesity, but we also see weight loss-independent benefits that benefits patients that have this disease.<\/p>\n","protected":false},"excerpt":{"rendered":"Dr. Le Roux: So the most important thing of, you know, understanding from the SYNCHRONIZE studies is that…\n","protected":false},"author":2,"featured_media":564673,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-564672","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/564672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=564672"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/564672\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/564673"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=564672"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=564672"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=564672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}