fibrinogen<\/a>\u00a0concentrations within 24 hours of admission were significantly more likely to develop\u00a0DVT than those with lower levels.\u00a0<\/p>\nDeep Venous Thrombosis Burden After Hip Fracture\u00a0<\/p>\n
The study\u00a0evaluated 234 patients aged 60 years and older who were admitted with hip fracture between January 2020 and June 2023.\u00a0\u00a0<\/p>\n
Bilateral lower extremity Doppler ultrasound was performed within 24 hours of admission, while blood samples were collected before pharmacological thromboprophylaxis was\u00a0initiated.\u00a0\u00a0<\/p>\n
Among the study population, 50 patients developed\u00a0DVT, corresponding to an incidence of 21.4%.\u00a0\u00a0<\/p>\n
Patients in the thrombosis group had longer times from injury to admission and\u00a0exhibited\u00a0higher concentrations of fibrinogen and C-reactive protein, alongside lower albumin levels.\u00a0<\/p>\n
Fibrinogen Emerged as an Independent Risk Factor\u00a0<\/p>\n
Mean fibrinogen concentrations were significantly higher among patients who developed\u00a0DVT\u00a0compared with those who did not\u00a0(4.15\u00b11.11 g\/L versus 3.47\u00b10.84 g\/L)\u00a0<\/p>\n
Univariate analysis\u00a0demonstrated\u00a0a significant association between fibrinogen levels and\u00a0DVT.\u00a0Even after\u00a0accounting for\u00a0factors such as age and sex, fibrinogen\u00a0remained independently associated with\u00a0DVT.\u00a0<\/p>\n
When fibrinogen levels reached or exceeded 4.15 g\/L, the association strengthened further. These patients had a significantly elevated likelihood of\u00a0DVT\u00a0after multivariable adjustment.\u00a0\u00a0<\/p>\n
Diagnostic Performance and Clinical Implications\u00a0<\/p>\n
Further\u00a0analysis showed that fibrinogen\u00a0demonstrated\u00a0moderate predictive performance.\u00a0\u00a0<\/p>\n
A combined model incorporating fibrinogen, C-reactive protein, and time from injury to admission achieved the strongest discrimination.\u00a0By contrast, D-dimer showed limited diagnostic utility in this early admission setting,\u00a0<\/p>\n
The\u00a0researchers\u00a0concluded that elevated fibrinogen measured shortly after admission was independently associated with early\u00a0DVT\u00a0in older adults with hip fracture and could support early clinical risk assessment, while the role of D-dimer in this\u00a0timeframe\u00a0should be interpreted cautiously.\u00a0<\/p>\n
Future prospective studies could help confirm whether early fibrinogen testing improves risk stratification and guides thromboprophylaxis decisions in this high-risk patient group.\u00a0<\/p>\n
Reference\u00a0<\/p>\n
Lu D et al. Fibrinogen in early admission is an independent risk factor for early deep venous thrombosis in elderly patients with hip fracture. Sci Rep.\u00a02026;DOI:10.1038\/s41598-026-59049-x\u00a0<\/p>\n
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