{"id":568584,"date":"2026-07-26T07:08:09","date_gmt":"2026-07-26T07:08:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/568584\/"},"modified":"2026-07-26T07:08:09","modified_gmt":"2026-07-26T07:08:09","slug":"nabil-ismaili-the-era-of-precision-oncology-in-urothelial-carcinoma-has-truly-arrived","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/568584\/","title":{"rendered":"Nabil Ismaili: The Era of Precision Oncology in Urothelial Carcinoma Has Truly Arrived"},"content":{"rendered":"<p>Nabil Ismaili, Director of Medical Oncology and Radiotherapy Department at Mohammed VI University of Sciences and Health, shared on <a href=\"https:\/\/www.linkedin.com\/posts\/nabil-ismaili-454623359_her2-in-urothelial-cancer-ugcPost-7486296206361473025-4tHY\/?utm_source=social_share_send&amp;utm_medium=member_desktop_web&amp;rcm=ACoAABQ-URoBqA1vbRoT_Fh_MvU2auhEdZdteXg\" target=\"_blank\" rel=\"noopener nofollow\">LinkedIn<\/a>:<\/p>\n<p>\u201cThrilled to share that our editorial \u201cEmergence of HER2 as a Key Biomarker and Therapeutic Target in Advanced Urothelial Carcinoma\u201d was published in the World Journal of Clinical Oncology on July 24, 2026!<\/p>\n<p>This paper highlights the critical findings by Huang and He on HER2 overexpression in upper tract urothelial carcinoma and contextualizes them within the paradigm-shifting results of the phase 3 RC48-C016 trial, now published in The New England Journal of Medicine.<\/p>\n<p>Key takeaway<\/p>\n<p>The combination of disitamab vedotin (anti-HER2 ADC) plus toripalimab (anti-PD-1) has demonstrated:<\/p>\n<p>Median PFS: 13.1 vs 6.5 months (HR=0.36)<br \/>\nMedian OS: 31.5 vs 16.9 months (HR=0.54)<br \/>\nORR: 76.1% vs 50.2%<br \/>\nFavorable safety profile<\/p>\n<p>With nearly 50% of upper tract UC tumors expressing HER2, a substantial subset of patients may now benefit from this biomarker-driven therapy. The era of precision oncology in urothelial carcinoma has truly arrived.<\/p>\n<p>Grateful for the opportunity to contribute to this rapidly evolving field.\u201d<\/p>\n<p>Title: Emergence of HER2 as a Key Biomarker and Therapeutic Target in Advanced Urothelial Carcinoma<\/p>\n<p>Author: Nabil Ismaili<\/p>\n<p><a href=\"https:\/\/www.wjgnet.com\/2218-4333\/full\/v17\/i7\/116520.htm\" target=\"_blank\" rel=\"noopener nofollow\">Read the article<\/a>.<\/p>\n<p>Read also \u201c<a href=\"https:\/\/oncodaily.com\/genitourinary-oncology\/urothelial-carcinoma-ctdna\" rel=\"nofollow noopener\" target=\"_blank\">ctDNA Monitoring During EV \u00b1 Pembrolizumab in Advanced Urothelial Carcinoma<\/a>\u201d on OncoDaily.<\/p>\n<p><a href=\"https:\/\/oncodaily.com\/genitourinary-oncology\/urothelial-carcinoma-ctdna\" rel=\"nofollow noopener\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-539575\" src=\"https:\/\/www.newsbeep.com\/ie\/wp-content\/uploads\/2026\/07\/ctDNA-urothelial-Carcinoma-800x450.webp\" alt=\"ctDNA urothelial Carcinoma\" width=\"800\" height=\"450\" title=\"Nabil Ismaili: The Era of Precision Oncology in Urothelial Carcinoma Has Truly Arrived 2\"  \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Nabil Ismaili, Director of Medical Oncology and Radiotherapy Department at Mohammed VI University of Sciences and Health, shared&hellip;\n","protected":false},"author":2,"featured_media":568585,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[61,60,80],"class_list":["post-568584","post","type-post","status-publish","format-standard","has-post-thumbnail","category-technology","tag-ie","tag-ireland","tag-technology"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/568584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=568584"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/568584\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/568585"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=568584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=568584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=568584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}