{"id":572209,"date":"2026-07-28T14:35:20","date_gmt":"2026-07-28T14:35:20","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/572209\/"},"modified":"2026-07-28T14:35:20","modified_gmt":"2026-07-28T14:35:20","slug":"better-safety-profile-tr-reduction-with-t-teer-than-ttva-similar-outcomes-at-1-year","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/572209\/","title":{"rendered":"Better Safety Profile, TR Reduction With T-TEER Than TTVA, Similar Outcomes at 1 Year"},"content":{"rendered":"<p>In patients with severe secondary tricuspid regurgitation (TR), tricuspid valve transcatheter edge-to-edge repair (T-TEER), compared with transcatheter tricuspid valve annuloplasty (TTVA), showed a more favorable safety profile and <a href=\"https:\/\/www.jacc.org\/doi\/10.1016\/j.jacadv.2026.103033\" target=\"_blank\" rel=\"nofollow noopener\">a more effective and durable reduction in TR<\/a>, while clinical outcomes at one year were similar with both strategies, according to research published July 22 in JACC: Advances.<\/p>\n<p>Investigators Jennifer von Stein, MD, et al., evaluated procedural and clinical outcomes among 111 propensity-matched pairs treated at European centers between 2017 and 2024. Patients treated with T-TEER using the PASCAL system (n=882) had a median age of 81 years, and 52% were women; those treated with TTVA using Cardioband (n=240) had a median age of 79 years, and 76% were women.<\/p>\n<p>Results showed that more patients treated with T-TEER than with TTVA achieved the primary endpoints of residual TR \u22641+ (50% vs. 34%) and TR \u22642+ (88% vs. 68%; p&lt;0.05 for all); rates of \u22652-grade TR reduction from baseline to discharge were similar.<\/p>\n<p>Among secondary endpoints, the procedural complication rate was lower with T-TEER than with TTVA (5% vs. 20%; p&lt;0.001). This included fewer access-site complications (0.9% vs. 2.7%), major bleeding events (1.1% vs. 7.2%) and cases of acute kidney injury (0.0% vs. 7.2%).<\/p>\n<p>At one year, freedom from all-cause mortality or first heart failure hospitalization was similar with T-TEER and TTVA: 75% vs. 80% (p=0.408). Reintervention rates were low and comparable (1.8% vs. 2.7%; p&gt;0.999). Additionally, no significant difference was observed in NYHA functional class improvement, with the proportion of patients in NYHA functional class \u2264II increasing from 16% to 64% after T-TEER and from 14% to 63% after TTVA.<\/p>\n<p align=\"center\"><img decoding=\"async\" class=\"w_70:md w_100\" src=\"https:\/\/www.newsbeep.com\/ie\/wp-content\/uploads\/2026\/07\/Von-Stein-Central-Illustration.jpg\" alt=\"JACC Central Illustration depicting the clinical outcomes of T-TEER vs. TTVA in contemporary transcatheter treatment of tricuspid regurgitation.\"\/><\/p>\n<p>Noting that this is the largest comparison of T-TEER and TTVA for severe secondary TR to date, the authors write, &#8220;These findings highlight the importance of procedural safety and durable TR reduction, while underscoring the complexity of translating procedural success into early clinical benefit and the need for longer-term evaluation.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"In patients with severe secondary tricuspid regurgitation (TR), tricuspid valve transcatheter edge-to-edge repair (T-TEER), compared with transcatheter tricuspid&hellip;\n","protected":false},"author":2,"featured_media":59664,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-572209","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/572209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=572209"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/572209\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/59664"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=572209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=572209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=572209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}