{"id":575664,"date":"2026-07-30T15:36:50","date_gmt":"2026-07-30T15:36:50","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/575664\/"},"modified":"2026-07-30T15:36:50","modified_gmt":"2026-07-30T15:36:50","slug":"case-series-supports-high-dose-oral-vitamin-d-for-cancer-therapy-related-skin-toxicities","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/575664\/","title":{"rendered":"Case Series Supports High-Dose Oral Vitamin D for Cancer Therapy\u2013Related Skin Toxicities"},"content":{"rendered":"

A retrospective multicenter case series published by Patil et al in JAMA Dermatology<\/a> found high-dose oral vitamin D therapy to be associated with rapid symptomatic and objective improvement in chemotherapy- and radiation therapy\u2013induced skin toxicities, without treatment-related adverse events.<\/p>\n

\u201cSevere cutaneous toxic effects from chemotherapy and radiation [therapy] often require treatment interruptions,\u201d the investigators commented. \u201cThis case series shows that as cancer treatments grow increasingly complex, incorporating [high-dose oral vitamin D] into supportive care protocols may minimize treatment interruptions, mitigate cutaneous toxic effects, and improve patient outcomes.\u201d<\/p>\n

Study Details<\/p>\n

The investigators evaluated 33 patients (mean age = 60.9 years; 19 [58%] female), including 28 (85%) with toxic erythema of chemotherapy and 5 (15%) with acute radiation dermatitis, who were treated at three academic medical centers between December 2021 and January 2024. Patients received one or two 100,000-IU doses of oral cholecalciferol or ergocalciferol and had at least 10 days of follow-up.<\/p>\n

As primary outcomes, the investigators assessed time to patient-reported symptomatic relief and clinician-assessed objective improvement in erythema (using a 5-point Likert scale). Changes in serum calcium levels and the ability to continue anticancer therapy were evaluated as secondary outcomes.<\/p>\n

Key Findings<\/p>\n

Within 10 days of treatment, 26 of 30 patients (87%) reported subjective symptom relief, and 23 (77%) had clinician-confirmed clinical improvement. The median time to improvement was 5 days (range = 1\u201328 days) overall and 3 days (range = 1\u201316 days) among the 12 inpatients. The mean Likert erythema score decreased over the 10-day follow-up, from 4.36 at baseline to 2.21. The most rapid responses were observed among patients with neutrophilic eccrine hidradenitis and Stevens-Johnson syndrome\/toxic epidermal necrolysis\u2013like subtypes.<\/p>\n

The investigators reported no meaningful changes in serum calcium levels, and 24 of 33 patients (73%) continued anticancer therapy without interruption. No treatment-related adverse events were documented.<\/p>\n

\u201cPatients who received high-dose oral vitamin D therapy were subsequently noted to have rapid improvement in radiation [therapy]\u2013 and chemotherapy-related toxic effects of the skin without any substantial safety concerns,\u201d the investigators concluded. \u201c[High-dose oral vitamin D] warrants further exploration to define its role in the evolving oncodermatology landscape, where rapid, effective, and safe interventions are urgently needed, particularly for toxic effects from chemotherapy and radiation [therapy].\u201d<\/p>\n

Christopher Iriarte, MD, of Beth Israel Deaconess Medical Center, Boston<\/a>, is the corresponding author of the JAMA Dermatology article.\u00a0<\/p>\n

Disclosure: For full disclosures of the study authors, visit jamanetwork.com<\/a>.\u00a0 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"A retrospective multicenter case series published by Patil et al in JAMA Dermatology found high-dose oral vitamin D…\n","protected":false},"author":2,"featured_media":575665,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-575664","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/575664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=575664"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/575664\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/575665"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=575664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=575664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=575664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}