{"id":579048,"date":"2026-08-01T15:56:08","date_gmt":"2026-08-01T15:56:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/579048\/"},"modified":"2026-08-01T15:56:08","modified_gmt":"2026-08-01T15:56:08","slug":"pmos-and-type-1-diabetes-lipid-profiles-studied","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/579048\/","title":{"rendered":"PMOS and Type 1 Diabetes Lipid Profiles Studied"},"content":{"rendered":"

Polyendocrine metabolic ovarian syndrome\u00a0was not associated with worse lipoprotein or inflammatory glycoprotein profiles in women with\u00a0Type 1 diabetes<\/a>, according to a\u00a0cross-sectional\u00a0study.\u00a0<\/p>\n

Researchers evaluated 147 premenopausal women with\u00a0Type 1 diabetes\u00a0(T1D), including 30 with\u00a0polyendocrine metabolic ovarian syndrome<\/a>\u00a0(PMOS)\u00a0and 117 without the condition.\u00a0\u00a0<\/p>\n

Lipoprotein and inflammatory glycoprotein profiles were characterised using proton nuclear magnetic resonance\u00a0(proton NMR)\u00a0spectroscopy.\u00a0\u00a0<\/p>\n

The\u00a0researchers\u00a0also compared women with both\u00a0T1D\u00a0and\u00a0PMOS\u00a0with 293 women who had\u00a0PMOS\u00a0without\u00a0T1D, including 249 with normal glucose tolerance and 44 with abnormal glucose tolerance.\u00a0\u00a0<\/p>\n

After adjustment for age and age at diabetes diagnosis, no significant differences were\u00a0identified\u00a0in lipoprotein or glycoprotein variables between women with\u00a0T1D\u00a0with or without\u00a0PMOS.\u00a0\u00a0<\/p>\n

An initial\u00a0increase in very\u00a0low-density\u00a0lipoprotein\u00a0(VLDL)\u00a0cholesterol lost significance after adjustment for confounding factors.\u00a0\u00a0<\/p>\n

Distinct Lipoprotein Patterns Emerged\u00a0<\/p>\n

Clear differences\u00a0emerged\u00a0when women with both conditions were compared with women who had\u00a0PMOS\u00a0alone.\u00a0\u00a0<\/p>\n

Women with abnormal glucose tolerance and\u00a0PMOS\u00a0showed higher concentrations of\u00a0VLDL\u00a0cholesterol,\u00a0VLDL\u00a0triglycerides, and\u00a0VLDL\u00a0particle numbers, alongside lower high-density lipoprotein\u00a0(HDL)\u00a0cholesterol concentrations.\u00a0<\/p>\n

By contrast, women\u00a0with\u00a0T1D\u00a0and\u00a0PMOS\u00a0had higher concentrations of\u00a0low-density\u00a0lipoprotein\u00a0(LDL)\u00a0cholesterol and\u00a0HDL\u00a0cholesterol, increased total and medium\u00a0HDL\u00a0particle numbers, and larger\u00a0LDL\u00a0particles.\u00a0\u00a0<\/p>\n

However, they also showed the highest levels of small\u00a0HDL\u00a0particles and the smallest average\u00a0HDL\u00a0particle size among the groups studied.\u00a0<\/p>\n

Inflammatory Markers Highlight Cardiometabolic Differences\u00a0<\/p>\n

Inflammatory glycoproteins were significantly elevated in women with\u00a0T1D\u00a0and\u00a0PMOS\u00a0and in those with abnormal glucose tolerance and\u00a0PMOS, compared with women with\u00a0PMOS\u00a0and normal glucose tolerance.\u00a0\u00a0<\/p>\n

The study also\u00a0identified\u00a0strong correlations between inflammatory glycoproteins and\u00a0VLDL-related measures in specific sub-groups, suggesting links between inflammation and lipid metabolism.\u00a0<\/p>\n

Overall, the findings\u00a0indicated\u00a0that coexisting\u00a0PMOS\u00a0did not worsen circulating lipoprotein or inflammatory glycoprotein profiles in women with\u00a0T1D.\u00a0\u00a0<\/p>\n

Nevertheless, the presence of potentially harmful\u00a0HDL\u00a0sub-classes may\u00a0warrant\u00a0further investigation.\u00a0\u00a0<\/p>\n

The\u00a0researchers\u00a0concluded that prospective studies are needed to clarify the\u00a0long-term\u00a0cardiovascular implications of hyperandrogenism and\u00a0PMOS\u00a0in women with\u00a0T1D.\u00a0<\/p>\n

Reference\u00a0<\/p>\n

Bayona Cebada A et al. Lipoprotein and inflammatory glycoprotein profiles in women with polycystic ovary syndrome alone or in association with type 1 diabetes. Sci Rep.\u00a02026;DOI:10.1038\/s41598-026-62157-3\u00a0<\/p>\n

Featured\u00a0image:\u00a0(JLco) Julia Amaral\u00a0on\u00a0Adobe Stock\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Polyendocrine metabolic ovarian syndrome\u00a0was not associated with worse lipoprotein or inflammatory glycoprotein profiles in women with\u00a0Type 1 diabetes,…\n","protected":false},"author":2,"featured_media":579049,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-579048","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/579048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=579048"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/579048\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/579049"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=579048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=579048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=579048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}