In this Review article, which was recently published in Leukemia & Lymphoma, the authors evaluate the efficacy and safety of menin inhibitor-based therapy in adults with relapsed\/refractory acute myeloid leukemia. Abstract Menin inhibitors (MI) are promising targeted therapies for acute myeloid leukemia (AML), particularly in NPM1-mutated and KMT2A-rearranged disease. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of MI-based therapy in adults with relapsed\/refractory AML. A search of six databases through January 2026 identified 14 studies including 784 treated patients. Among response-evaluable cohorts (k\u2009=\u200922;\u00a0n\u2009=\u2009579), the pooled overall response rate (ORR) was 54.6% (95% CI 46.4\u201362.6;…<\/p>\n
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It’s completely free<\/p>\n","protected":false},"excerpt":{"rendered":"In this Review article, which was recently published in Leukemia & Lymphoma, the authors evaluate the efficacy and…\n","protected":false},"author":2,"featured_media":582842,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[67173,103,61,60,245950,245951,245952],"class_list":["post-582841","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-acute-myeloid-leukemia","tag-health","tag-ie","tag-ireland","tag-menin-inhibitors","tag-refractory-disease","tag-relapse"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/582841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=582841"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/582841\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/582842"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=582841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=582841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=582841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}