tetanus-diphtheria<\/a> booster vaccine.\u00a0<\/p>\nThe randomised trial involved healthy adult participants who received either the SPVX02 vaccine or established comparator vaccines.\u00a0\u00a0<\/p>\n
Researchers found that\u00a0candidates\u00a0who received the\u00a0\u2018fridge-free\u2019\u00a0dose\u00a0produced immune responses comparable to existing approved vaccines\u00a0whilst no serious adverse reactions or events occurred.\u00a0<\/p>\n
The only notable side effects\u00a0were\u00a0comparable\u00a0to those\u00a0observed\u00a0with currently available tetanus-diphtheria booster vaccines.\u00a0These included\u00a0pain\u00a0on the injection site,\u00a0headaches\u00a0and chills\u00a0among other minor symptoms\u00a0in the period after administration.\u00a0\u00a0\u00a0<\/p>\n
Reducing Vaccine Waste\u00a0<\/p>\n
Researchers\u00a0also argue that removing\u00a0the need for refrigeration could help prevent\u00a0the current huge levels of\u00a0vaccine wastage.\u00a0The World Health Organization estimates that\u00a0a up to 50% of\u00a0unused\u00a0vaccines are\u00a0disposed of\u00a0globally every year.\u00a0<\/p>\n
While\u00a0there\u00a0are\u00a0several\u00a0reasons for why a vaccine may be thrown out before it is given to a patient, including\u00a0expiration\u00a0dates and damage, a major cause is failures in the cold chain.\u00a0\u00a0<\/p>\n
Separate data\u00a0from the study\u00a0shows the components of the\u00a0new\u00a0vaccine\u00a0formula\u00a0also survived\u00a0cycling between temperatures of -20\u00b0C\u00a0and +40\u00b0C.\u00a0<\/p>\n
This\u00a0could\u00a0allow\u00a0the\u00a0vaccine\u00a0to be\u00a0transported between extremely cold and hot climates in quick succession, such\u00a0as\u00a0from\u00a0an\u00a0aircraft\u00a0hold\u00a0to the back of a truck in the heat.\u00a0<\/p>\n
Next Steps for Vaccine Development\u00a0<\/p>\n
Researchers\u00a0are confident\u00a0that the\u00a0same stabilisation\u00a0technology\u00a0could potentially be applied to other vaccines and biological products.\u00a0<\/p>\n
Although the phase I findings provide early evidence that SPVX02 is safe and capable of generating an immune response, larger clinical trials will be needed before the\u00a0vaccine\u00a0or technology\u00a0can be approved for widespread use.\u00a0<\/p>\n
Phase\u00a0II and phase III\u00a0trials\u00a0are already\u00a0planned, and further research will investigate temperature stability at\u00a0even\u00a0higher temperatures, as well as\u00a0technology application to other vaccines and biological products.\u00a0<\/p>\n
If successful, the technology could\u00a0represent\u00a0a major shift in vaccine distribution\u00a0and immunisation efforts\u00a0globally.\u00a0<\/p>\n
Reference<\/p>\n
Reed T et al. Safety, tolerability, and immunogenicity of SPVX02, a room temperature-stabilised tetanus-diphtheria vaccine, compared to two established tetanus-diphtheria booster vaccines: a multicentre, single-blind, randomised, first-in-human phase 1 trial in the UK. eClinicalMedicine. 2026<\/p>\n
Featured Image:\u00a0\u202fMikhailov Studio\u00a0on\u00a0AdobeStock\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"HUMAN TRIALS\u00a0of\u00a0the first\u00a0\u2018fridge-free\u2019\u00a0vaccines that could reduce waste and barriers to global\u00a0vaccine\u00a0deployment have\u00a0been successful.\u00a0 Findings from a\u00a0phase I trial…\n","protected":false},"author":2,"featured_media":586073,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-586072","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/586072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=586072"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/586072\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/586073"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=586072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=586072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=586072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}