{"id":587828,"date":"2026-08-09T09:56:12","date_gmt":"2026-08-09T09:56:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/587828\/"},"modified":"2026-08-09T09:56:12","modified_gmt":"2026-08-09T09:56:12","slug":"mri-diagnostic-model-for-hbv-liver-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/587828\/","title":{"rendered":"MRI Diagnostic Model for HBV Liver Cancer"},"content":{"rendered":"<p>A NEW MRI diagnostic model combining serum biomarkers with magnetic resonance imaging features accurately distinguished scirrhous hepatocellular carcinoma (SHCC) from intrahepatic mass-forming cholangiocarcinoma (IMCC) in patients with <a href=\"https:\/\/www.emjreviews.com\/hepatology\/article\/towards-a-functional-cure-for-chronic-hbv-infection-progress-setbacks-and-new-hope\/\" rel=\"nofollow noopener\" target=\"_blank\">hepatitis B virus (HBV) infection<\/a>, achieving high diagnostic accuracy in both the training and external validation cohorts.<\/p>\n<p>SHCC is a rare form of hepatocellular carcinoma, whereas IMCC is a primary bile duct cancer that develops within the liver. Differentiating the two cancers before treatment can be challenging, but accurate diagnosis is important because management strategies differ.<\/p>\n<p>The retrospective multicentre study analysed 183 cases from HBV-infected patients across three centres, including 63 pathologically confirmed SHCC and 120 IMCC cases.<\/p>\n<p>MRI Features Strengthened Diagnostic Accuracy<\/p>\n<p>Researchers assessed clinicopathological characteristics alongside gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI findings to identify factors that distinguished SHCC from IMCC. Compared with IMCC, SHCC showed a significantly lower incidence of necrosis in both the training and validation cohorts (training:\u00a0p=\u20090.03; validation:\u00a0p=0.002).<\/p>\n<p>Multivariable analysis identified three imaging features as independent diagnostic indicators: non-thin rim enhancement during the arterial phase, an enhancing capsule, and signal loss on opposed-phase T1-weighted imaging. When combined with relevant serum biomarkers, these imaging features produced a diagnostic model with an area under the curve (AUC) of 0.951, alongside a sensitivity of 85.9% and specificity of 88.4% in the training cohort.<\/p>\n<p>Validation Supported Clinical Utility<\/p>\n<p>External validation demonstrated similarly strong performance, with an AUC of 0.939, sensitivity of 85.0%, and specificity of 88.9%. Decision curve analysis also indicated a positive net benefit across a range of threshold probabilities, supporting the model\u2019s potential clinical utility.<\/p>\n<p>Potential to Inform Personalised Treatment<\/p>\n<p>The findings suggested that combining Gd-EOB-DTPA-enhanced MRI characteristics with serum biomarkers could provide clinicians with a reliable preoperative approach for distinguishing SHCC from IMCC in HBV-infected patients. Improved diagnostic confidence in this high-risk population could help inform personalised treatment planning. However, because the study only included patients with HBV infection, the findings should be interpreted within that clinical setting.<\/p>\n<p>Reference<\/p>\n<p>He H et al. Differentiating scirrhous hepatocellular carcinoma from intrahepatic mass-forming cholangiocarcinoma based on Gd-EOB-DTPA-enhanced MRI and serum biomarkers in an HBV-positive high-risk cohort: a multi-center study. Eur Radiol. 2026;DOI:10.1007\/s00330-026-12749-4.<\/p>\n<p>Featured image: Sorlolve on Adobe Stock<\/p>\n","protected":false},"excerpt":{"rendered":"A NEW MRI diagnostic model combining serum biomarkers with magnetic resonance imaging features accurately distinguished scirrhous hepatocellular carcinoma&hellip;\n","protected":false},"author":2,"featured_media":587829,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-587828","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/587828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=587828"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/587828\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/587829"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=587828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=587828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=587828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}