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Credit: iStock.com\/andreswd<\/p>\n
The Irish Society for Rheumatology 2026 Autumn Meeting received a practical summary of the latest updates in guideline-directed care of polymyalgia rheumatica (PMR) from Dr Sarah Mackie, Associate Professor of Vascular Rheumatology, University of Leeds; and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust, UK. Her talk summarised the recent guideline revisions by the European Alliance of Associations for Rheumatology (EULAR) and forthcoming updates from the British Society for Rheumatology (BSR). She described EULAR as taking \u201cperhaps a more radical approach\u201d, while the BSR approach was more aligned with existing practice, likening the two to the \u201ctortoise and hare\u201d.<\/p>\n
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Dr Sarah Mackie<\/p>\n
Dr Mackie opened her talk with a comparison between software and clinical guideline updates, describing how both software and clinical practice can benefit from things like \u201cbug fixes, performance updates, and additional new features\u201d.<\/p>\n
\u201cOur knowledge about PMR is constantly advancing; its relationship with other diseases, the way we manage it \u2013 it\u2019s all advancing. So, the guidelines need to keep up with all the science, knowledge, and technology out there.\u201d<\/p>\n
Myths and challenges in PMR<\/p>\n
Dr Mackie addressed the longstanding discordance between \u201cstandard messaging in PMR and what happens in real life\u201d. She challenged the common misconceptions that corticosteroids are the only treatment option and that PMR resolves after two years. \u201cIt\u2019s true that the average patient will be off steroids within two years, but this is often misinterpreted that PMR goes away after two years,\u201d she explained. Dr Mackie also identified the challenge of what she termed \u201cthe PMR paradox\u201d of corticosteroid treatment.<\/p>\n
\u201cThe treatment is steroids, but we\u2019ve got to get you off the steroids \u2013 this is what we tell patients. It\u2019s all quite a contradiction and it doesn\u2019t make sense to them.\u201d<\/p>\n
Delegates heard that these misunderstandings, alongside a reluctance to reduce steroids, can contribute to a \u201cnon-consultation, non-referral vacuum\u201d. Patients may stop consulting their GP because they fear being told to taper their steroids, and at the same time, GPs may be reluctant to refer patients to rheumatology in case the patient is advised to taper their steroids \u2013 both concerned that tapering could leave symptoms inadequately controlled. Dr Mackie also noted that \u201cmost patients and GPs are unaware that DMARDs [disease-modifying anti-rheumatic drugs] may be an option\u201d.<\/p>\n
To refer or not to refer?<\/p>\n
EULAR recommends that all patients with suspected PMR should be referred for specialist expertise, and that corticosteroid treatment should be delayed until the diagnosis has been confirmed. Dr Mackie noted that while these recommendations may be feasible individually, implementing them together could prove challenging in healthcare systems where access to rheumatology is limited. By comparison, the BSR guidance states that uncomplicated cases should be diagnosed and managed by GPs, with rheumatology input when required.<\/p>\n
Dr Mackie acknowledged that the EULAR guidelines need to be applicable across all EULAR countries, with suspected PMR being routinely referred to rheumatology in many of them, unlike the UK and Ireland, where PMR is primarily managed by the GP. The guidelines do recognise that access to specialist services varies between regions. In England, she noted, expertise in PMR has increasingly developed within primary care \u201cbecause they\u2019ve been doing it for decades\u201d. Dr Mackie also pointed to differences in the composition of the two guideline working groups. \u201cWe had GPs as well as rheumatologists (in the BSR group); I don\u2019t think they had primary care physicians on the EULAR guideline group,\u201d she said. \u201cBSR guidelines had to be acceptable to primary care because we have to work with primary care.\u201d<\/p>\n
Diagnosing PMR<\/p>\n
Dr Mackie warned of a growing risk of misdiagnosis in PMR, particularly in the absence of a definitive diagnostic test. EULAR states that PMR diagnosis should be based on a combination of typical signs and symptoms, alongside exclusion of potential mimicking conditions, she said. Both EULAR and BSR caution against using classification criteria as a diagnostic algorithm, the conference heard.<\/p>\n
\u201cWe don\u2019t want to overuse classification criteria because there is a risk that it will be used as a diagnostic algorithm, and that\u2019s not what classification criteria were ever developed or intended for. I hope that message is heard.\u201d<\/p>\n
Artificial intelligence (AI) is likely to add another dimension to the diagnostic process and to patient-doctor interactions. \u201cAI is really going to affect how we diagnose,\u201d Dr Mackie said. While liability will remain with clinicians, she noted that the profession will need to work out how best to navigate AI and its \u201cvery rapid progression\u201d.<\/p>\n
Dr Mackie also questioned what constitutes sufficient expertise to manage patients with relapsing-remitting PMR. While EULAR guidance recommends that such patients should be managed in \u201cexpert hands\u201d, it does not define what constitutes an expert, she said. The guidance also introduces the concept of an \u201cexpert centre\u201d, but again without clearly defining what this means in practice.<\/p>\n
\u201cHow do we know a centre is expert?\u201d Dr Mackie said. \u201cHopefully we\u2019ll hear more from EULAR on that.\u201d<\/p>\n
New treatments and advances<\/p>\n
Turning to treatment advances, Dr Mackie highlighted what she described as an encouraging period for PMR research. \u201cThe good news is that there have been loads of trials in PMR for the first time in many decades,\u201d she said about studies that are beginning to identify treatments that can reduce reliance on corticosteroids. Several pivotal trials have evaluated potential glucocorticoid-sparing therapies, including interleukin-6 (IL-6) inhibitors, IL-17 inhibitors, B-cell depletion, and Janus kinase (JAK) inhibitors. Among the trials discussed were PMR-SPARE, SEMAPHORE, REPLENISH, and SAPHYR.<\/p>\n
\u201cMethotrexate is already available as a treatment option,\u201d Dr Mackie continued, noting it is first-line in BSR guidance, in contrast to IL-6 inhibition in EULAR guidance \u2013 highlighting another key difference between the two. \u201cMethotrexate is recommended for consideration in patients who are prone to relapse,\u201d she said. The BSR guidance encourages GPs to consider an early discussion about steroid-sparing treatment, helping to challenge the perception that corticosteroids are the only available treatment option.<\/p>\n
Dr Mackie concluded with an overview of recent advances in the understanding of the underlying biology and presentation of PMR, including the identification of symmetrical inflammatory lesions \u2013 a potential imaging \u201csignature\u201d of the disease \u2013 as well as genetic associations and the diversity of potential symptom triggers, like viruses and vaccines. She finished on an optimistic note, returning to her earlier comparison between the EULAR and BSR approaches: \u201cNo matter whether we use the tortoise or hare approach, I think the prospect for patients will improve.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"Credit: iStock.com\/andreswd The Irish Society for Rheumatology 2026 Autumn Meeting received a practical summary of the latest updates…\n","protected":false},"author":2,"featured_media":667086,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-667085","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/667085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=667085"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/667085\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/667086"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=667085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=667085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=667085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}