{"id":668911,"date":"2026-10-29T14:32:30","date_gmt":"2026-10-29T14:32:30","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/668911\/"},"modified":"2026-10-29T14:32:30","modified_gmt":"2026-10-29T14:32:30","slug":"researchers-examine-whether-pill-could-be-used-to-treat-diabetic-retinopathy","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/668911\/","title":{"rendered":"Researchers examine whether pill could be used to treat diabetic retinopathy"},"content":{"rendered":"<p>A new study published in <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aed8692\" target=\"_blank\" rel=\"nofollow noopener\">Science Translational Medicine<\/a> has examined whether danegaptide could be used to prevent vision loss in non-proliferative diabetic retinopathy (NPDR). <\/p>\n<p>As part of research performed in collaboration with Breye Therapeutics, researchers from Trinity College Dublin administered danegaptide to 24 patients with NPDR. <\/p>\n<p>They found that the oral medication was safe and well-tolerated, while more than half (55%) of participants demonstrated early signs of biological activity \u2013 such as reduced retinal leakage, decreased central subfield thickness, and resolution of intra-retinal fluid cysts.<\/p>\n<p>Experiments observing pre-clinical models of NPDR found that administering danegaptide reduced blood vessel leakage in the retina, prevented inner blood-retina barrier breakdown, and reversed retinal oedema. <\/p>\n<p>The researchers found that the efficacy of the treatment in pre-clinical models was comparable to injectable therapies for NPDR. <\/p>\n<p>Senior author, Professor Matthew Campbell, chair of neurovascular genetics at Trinity College Dublin, highlighted that managing diabetic eye disease has long been constrained by the invasive nature of existing treatments. <\/p>\n<p>\u201cOur findings demonstrate that a simple oral pill can effectively target and repair the inner blood-retina barrier. This potentially offers a non-invasive, preventive path forward that could protect vision in both eyes simultaneously, long before severe sight loss takes hold,\u201d he said. <\/p>\n","protected":false},"excerpt":{"rendered":"A new study published in Science Translational Medicine has examined whether danegaptide could be used to prevent vision&hellip;\n","protected":false},"author":2,"featured_media":668912,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[283266,283267,103,61,60,164074,164073,283268,283269,15120],"class_list":["post-668911","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-breye-therapeutics","tag-danegaptide","tag-health","tag-ie","tag-ireland","tag-optometry-today","tag-ot","tag-professor-matthew-campbell","tag-science-translational-medicine","tag-trinity-college-dublin"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/668911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=668911"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/668911\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/668912"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=668911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=668911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=668911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}