In previous studies, the research group has shown that cancer cells inside tumours can be reprogrammed into dendritic cells \u2013 an important type of immune cell that helps the body mount an antitumour immune response. \u201cIn the new study, we show that these reprogrammed cells can also promote the formation of TLSs.\u201d\u00a0<\/p>\n
Using the method of reprogramming tumour cells into dendritic cells, the researchers have now been able to investigate what happens in the tumour tissue when TLSs form. They have also demonstrated how reprogrammed cells contribute to organising the immune system\u2019s attack on the tumour. In experiments in mice, the researchers showed that the method can activate the immune system across several different types of cancer, including melanoma<\/a>, colorectal<\/a>, bladder, breast<\/a> and pancreatic cancer.\u00a0<\/p>\n The results suggest that cell reprogramming could become a way of making tumours more responsive to immunotherapy and, in the long term, help more patients benefit from this treatment. \u201cOur study shows that this is possible in several cancer types, including tumours that are usually resistant to immunotherapy. It could pave the way for new immunotherapies that make it easier to treat tumours the immune system has previously found difficult to attack,” concludes Filipe Pereira.\u00a0<\/p>\n The next step is to better understand which signals cause TLS to form and persist over time, and how the method can be combined with current immunotherapies. The researchers also want to investigate how different immune cells work together to create a long-lasting response against the tumour.\u00a0<\/p>\n Source: Lund University\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"In previous studies, the research group has shown that cancer cells inside tumours can be reprogrammed into dendritic…\n","protected":false},"author":2,"featured_media":679345,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60,287523,233830,287524],"class_list":["post-679344","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland","tag-led-by-lunduniversity","tag-published-in-cp-immunity-bsky-social","tag-published-in-immunity-cellpress-brled-by-cellreprolab-bsky-social-from-lund-university-bsky-social"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/679344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=679344"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/679344\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/679345"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=679344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=679344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=679344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}