Recent large-scale research has put the spotlight on a nuance that often looms under the surface of antidepressant prescribing: not all antidepressants are physiologically equal.
A new systematic review and network meta-analysis of 151 trials, involving more than 58,000 patients, found clinically meaningful differences between drugs in weight change, heart rate and blood pressure —even within 6-8 weeks of treatment.
AusDoc has developed a guide that summarises the most relevant physiological effects of commonly prescribed antidepressants based on the study, which was published in The Lancet.
Methodological note: Data from Pillinger et al., The Lancet (2025). Approximate short-term (6-8 week) changes in weight, cardiometabolic and hepatic markers were derived from reported mean differences and standardised mean differences, converted to clinically relevant estimates using a pooled standard deviation of ≈ 2 kg for weight and qualitative summaries for other measures.
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