Exercise training benefits patients with HIV below the surface

Medscape news story

A 16-week exercise training program showed broad benefits, including cellular damage repair and slowdown in epigenetic aging, in people with HIV (PWH), based on new data presented at CROI 2026.

Exercise improves overall health and slows the progression of aging-related comorbidities in PWH, but understanding of the feasibility and effects of exercise in this population is limited. Evaluation of exercise-related changes at the cellular level may inform targeted strategies to enhance the benefits of exercise.

The researchers designed a study to evaluate the impact of a 16-week exercise intervention on muscle DNA methylation in older PWH using data from the HEALTH trial. A better understanding of methylation changes will help clarify the mechanisms by which exercise affects physical function and recovery over time.

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