The Myelofibrosis Treatment Market size is estimated to be
valued at USD 1.2 billion in 2025 and is expected to reach USD
2.75 billion by 2032, exhibiting a compound annual growth rate (CAGR)
of 12.3% from 2025 to 2032. Myelofibrosis is a rare bone marrow
disorder that disrupts the body’s normal process of blood cell production. It
occurs when fibrous or scar tissue forms within the bone marrow, leading to scarring
that impairs its ability to generate adequate blood cells. Classified as a type
of chronic leukemia, myelofibrosis significantly affects healthy blood
formation.
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Global Myelofibrosis Treatment Market
Key Takeaways
According to Coherent Market Insights
(CMI), the global myelofibrosis treatment market size is projected to expand at
a CAGR of 12.3% during the forecast period, reaching USD 2.75 Bn by 2032, up
from USD 1.2 Bn in 2025.
JAK inhibitors continue to remain a
highly sought-after treatment for myelofibrosis, with the target segment
expected to account for 45% of the market share in 2025.
Based on route of administration,
oral segment is set to account for a prominent myelofibrosis treatment market
share in 2025.
North America is anticipated to
account for two-fifths of the global myelofibrosis treatment industry share in
2025.
Asia Pacific, with an estimated CAGR
of 14%, is expected to emerge as the most lucrative market for pharmaceutical
companies during the forecast period.
Rising Prevalence of Myelofibrosis
Spurring Market Growth
Coherent Market Insights’ new myelofibrosis
treatment market analysis offers insights into major factors fueling industry
growth. Increasing prevalence of myelofibrosis is one such prominent growth
driver.
The global incidence of myelofibrosis
is rising significantly, partly due to an aging global population and improved
awareness and diagnosis. This is driving demand for effective myelofibrosis
treatments, and the trend will likely continue in the coming years.
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High Treatment Costs and Side Effects
Limiting Market Growth
The global myelofibrosis treatment market
outlook appears promising, owing to rising myelofibrosis cases. However, high
treatment costs and side effects might slow down market growth to some extent
during the projection period.
Advanced myelofibrosis treatments,
such as JAK inhibitors, are very costly. For example, the average yearly list
price of Jakafi in the U.S. is about $17,150. This can limit patient access,
especially in low- and middle-income regions, thereby dampening overall
myelofibrosis treatment market demand.
In addition, long-term use of JAK
inhibitors can cause side effects such as blood abnormalities, infections, and
skin reactions. This may impact patient adherence and quality of life,
sometimes resulting in treatment discontinuation.
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Advancements in Targeted Therapies
Creating Growth Prospects
Targeted
therapies, especially Janus kinase (JAK) inhibitors like ruxolitinib,
fedratinib, pacritinib, and momelotinib, are revolutionizing treatment options
for myelofibrosis patients. These therapies have demonstrated efficacy in
reducing spleen size and alleviating symptoms.
They have the
tendency to significantly improve patient outcomes. Growing adoption of these
therapies is expected to create lucrative growth opportunities for
myelofibrosis treatment manufacturers during the forthcoming period.
Emerging Myelofibrosis Treatment Market
Trends
Combination
therapies are gaining traction in myelofibrosis management. For instance, using
ruxolitinib together with pelabresib has shown better results in clinical
trials. These combinations are designed to help patients who do not respond
well to JAK inhibitors or face side effects. The growing use of such
combination therapies is likely to drive the growth of the myelofibrosis
treatment market.
Ongoing
product launches and approvals are contributing to market expansion. Leading
players are striving to launch new products as well as receive approvals from
regulatory bodies. For example, GSK’s drug Omjjara recently received approval
in Japan for the treatment of myelofibrosis.
Strategies
like partnerships, acquisitions, and collaborations are becoming popular in the
myleofibrosis treatment landscape. Many pharmaceutical companies are partnering
with healthcare organizations to enhance myelofibrosis treatment accessibility.
For instance, Incyte Corporation’s recent collaboration with EuroBloodNet
improved treatment access in Eastern Europe.
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Analyst’s View
“The global myelofibrosis treatment industry is set to
exhibit robust growth, owing to rising diagnosed cases of myelofibrosis,
advancements in targeted therapies, growing popularity of combination
therapies, and ongoing new product launches and approvals,” said a senior CMI analyst.
Current Events and Their Impact on the Myelofibrosis
Treatment Market
Event
Description
and Impact
Regulatory Advances in JAK Inhibitor Approvals
Description: FDA has implemented
accelerated approval pathways for rare disease treatments.
o Impact: This allows novel myelofibrosis therapies
to enter the market faster, reducing development timelines and providing
patients with quicker access to new treatments.
Technological Advances in Precision Medicine
Description: AI-driven
drug discovery platforms are being applied to myelofibrosis research.
Impact: These
technologies accelerate the identification of new therapeutic targets
and shorten development timelines, improving the likelihood of
successful treatments.
Strategic Pharmaceutical Industry Consolidation
Description: Large pharmaceutical companies are
acquiring myelofibrosis-focused biotechnology firms.
Impact: This increases R&D investment
and commercialization capabilities for specialized treatments,
benefiting patients with more effective therapy options.
Competitor Insights
Key companies in myelofibrosis
treatment market report include:
– Novartis AG
– Incyte Corporation
– Bristol-Myers Squibb
Company
– Sanofi S.A.
– Pfizer Inc.
– CTI BioPharma Corp.
– Eli Lilly and Company
– Geron Corporation
– AbbVie Inc.
– Aclaris Therapeutics
Key Developments
·
In
March 2025, Mount Sinai’s Phase 3 trial showed that a new combination of medicines,
pelabresib and ruxolitinib, could help improve outcomes for patients with
myelofibrosis who hadn’t been treated before.
·
In
January 2024, the European Commission granted marketing authorization for Omjjara
(momelotinib). This makes Omjjara the first EU-approved medicine for treating
enlarged spleen or related symptoms in adults with myelofibrosis and moderate
to severe anemia.
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Market Segmentation
By
Treatment Type: JAK Inhibitors, Immunomodulatory Agents, Chemotherapy,
Stem Cell Transplantation, Others
By Route
of Administration: Oral, Injectable, Others
By
End-User: Hospitals, Specialty Clinics, Homecare Settings, Others
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Transplantation Market Outlook for 2025-2032
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