Mitochondrial checkpoint enables dendritic cells to activate T lymphocytes against viruses, tumors
A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial “checkpoint”…
New mRNA vaccine strategy dramatically amplifies cancer-fighting T cells
Engineers from the University of Houston, MIT and Harvard have developed a new mRNA-based strategy that dramatically amplifies…
A new combined therapy to boost the immune system against cancer
Cancer immunotherapy is built on a simple but powerful idea: the immune system can recognize and destroy cancer…
Single-cell sequencing reveals why some CAR-T therapies succeed while others fail
By mapping CAR-T cells one by one, researchers are uncovering the cellular traits that may separate durable cancer…
Kenyan bat coronavirus uses human CEACAM6 to enter cells, raising spillover concerns
A newly characterized bat coronavirus can latch onto a human cell receptor found in the lung, giving scientists…
Innovative light probes allow real-time visualization of cellular processes
Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and…
Targeting glutamine metabolism enhances CAR-macrophage cancer therapy
Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function. Specifically,…
How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
DNA origami vaccine platform shows promise against multiple infectious viruses
The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical…
Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia
Chimeric antigen receptor T (CAR T) cell therapy represents a milestone in leukemia treatment. CAR T works by…
Optimized costimulatory domains boost tumor killing in CAR NK cells
Researchers at the Ribeirão Preto Blood Center and the Center for Cell-Based Therapy (CTC) conducted a study using the NK-92…