A novel gene expression stability metric to unveil homeostasis and regulation | Genome Biology
K-proportion and gene homeostasis Z-Index identify regulatory genes As cells of the same type and in the same…
Structural and evolutionary features of red algal UV sex chromosomes | Genome Biology
To define the male and female haplotypes of the sex-determining locus in Gracilaria species, we leveraged male reference…
SpatPPI: a geometric deep learning model for predicting protein–protein interactions involving intrinsically disordered regions | Genome Biology
Data preparation In this section, we introduce the details of the datasets used in this study, including the…
Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE | Genome Biology
Model overview We consider the following model to incorporate both additive and interaction effects: $${Y}_{i}={\sum }_{j=1}^{M}{G}_{ji}{\beta }_{j}+{\sum }_{j=1}^{M}{S}_{ji}{\gamma…
Boosting K-nearest neighbor regression performance for longitudinal data through a novel learning approach | BMC Bioinformatics
Variable-trajectory Let \(y_{it} \in {\mathbb{R}}\) denote the observed response value for the subject \(i \in \left\{ {1, \ldots…
Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals | Genome Biology
Individual-level quantification of NMD efficiency We quantified the individual-level NMD efficiency (iNMDeff) by utilizing matched RNA-seq and whole-exome…
Machine learning and statistical inference in microbial population genomics | Genome Biology
Blackwell GA, Hunt M, Malone KM, Lima L, Horesh G, Alako BTF, et al. Exploring bacterial diversity via…
Hybrid BAG-seq: DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples | Genome Biology
Experimental designSamples We obtained fresh tissue samples of primary tumors from five patients with uterine cancer (Additional file…
From gut to gamete: how the microbiome influences fertility and preconception health | Microbiome
Inhorn MC, Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in…
Advances in haplotype phasing and genotype imputation
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…
Genomenon and Compass Bioinformatics Partner to Transform Genomic Diagnostics in the U.S. and Japan
Mastermind® FLEX Data powers Compass Bioinformatics’s InheriNext® platform, bringing unparalleled genomic evidence to leading institutes across US, Japan,…
Fueling chromosomal gene diversification and artificial evolution with CRISPR | Genome Biology
Wilson DS, Keefe AD. Random mutagenesis by PCR. Curr Protoc Mol Biol. 2001;51:8–3. Google Scholar Reetz MT, Wu…