Characterization of induced cohesin loop extrusion trajectories in living cells
Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers
Genetic ancestry is a quantitative measure of inherited genetic variation and correlates with human migration patterns1. It contributes…
The occurrence of hyperthyroidism after thermal ablation for thyroid papillary carcinoma: a retrospective multicentre observational study | BMC Cancer
Treatment for benign thyroid nodules and PTC traditionally includes conventional surgical procedures and radioactive iodine treatment [1, 9,10,11,12,13].…
Global, regional, and national burden of lip and oral cavity cancer and projections to 2036 | BMC Cancer
Our comprehensive analysis of the GBD 2021 data elucidates significant temporal and spatial patterns in the global burden…
“Molecular dance” – key mechanism of cell movement finally decoded, offering new insights into cancer research
Inside every cell, a delicate network of protein filaments known as the cytoskeleton provides structure and stability. Actin…
Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health
Ethics Our research complies with all relevant ethical regulations. All studies included in this research were approved by…
Nucleotide dependency analysis of genomic language models detects functional elements
SpeciesLM training For SpeciesLM metazoa, we obtained metazoan genomes comprising 494 different species from the Ensembl 110 database36.…
Forensic genetics in the omics era
Jeffreys, A. J., Wilson, V. & Thein, S. L. Individual-specific ‘fingerprints’ of human DNA. Nature 316, 76–79 (1985).…
Dietary index for gut microbiota, genetic risk, and incidence of breast cancer: a prospective study | Breast Cancer Research
Study design and population Study design and methods of UK Biobank have been reported in detail previously [17].…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
α-L-fucosidase isoenzymes (FUCA1/FUCA2) as prognostic markers in gliomas: a comprehensive study | BMC Cancer
Clinical samples and ethics of study Sample acquisition: (1) Glioma tissues: 30 cases (25 grade II/III, 5 GBM;…
KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease
Precision Healthcare University Research Institute, Queen Mary University of London, London, UK Segun Fatumo, Oyesola Ojewunmi, Rebecca Camenzuli, Christopher Kintu & Claudia Langenberg…