New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
DNA origami vaccine platform shows promise against multiple infectious viruses
The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical…
Immune system dysfunction may fuel progressive heart failure after heart attacks
When the heart’s muscle is weakened or injured due to a heart attack, it can make it hard…
Chemotherapy-induced gut changes trigger anti-metastatic immune response
Chemotherapy commonly damages the intestinal lining, a well-known side effect. But this injury does not remain confined to…
Engineered extracellular vesicles enable antigen-specific regulatory T cell induction
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University…
Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes
Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion,…