Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice
A mouse study traces how immune cells activated in the intestine migrate to the dura and persist at…
Scientists traced a hidden immune route that may worsen tau-linked brain damage
Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…
Disrupted brain-immune signaling may help drive neurodegeneration
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
A striking immune cell pattern emerges around a person’s 100th birthday
Rare immune cells found at strikingly high levels in people who live beyond 110 reveal an unusual pattern…
Polydatin reduces ulcerative colitis by regulating intestinal immune cells
Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which recurrent intestinal inflammation can be difficult to…
KAIST study opens a new avenue for treating intractable brain tumors
Researchers have uncovered a clue to why immune checkpoint inhibitors-cancer therapies that release the immune “brakes” exploited by…
First human trial targets aging immune cells for healthier immunity
A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells…
Pim1 identified as promising therapeutic target for inflammatory arthritis treatment
The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
Nasal memory cells help slow influenza virus at entry
Memory cells in the nose slow the influenza virus as soon as it enters the body. They reduce…
How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
DNA origami vaccine platform shows promise against multiple infectious viruses
The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical…