Cell Adhesion - Israel News Beep

uPAR and its associated proteins induce multiorgan injury. Dysregulation of innate immunity caused by various physiological challenges, such as diabetes, hypertension, viral and bacterial infections, or smoking, leads to elevated suPAR levels and/or production of the D2D3 protein. Models illustrate the mechanisms through which these proteins cause injury to the kidney (A), pancreas (B), and cardiovascular system (C).

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A single immune protein may help explain why kidney and heart disease often develop together

January 7, 2026

A growing body of human, genetic, and experimental evidence suggests that suPAR may not only signal disease risk…