Data-driven modeling uncovers dynamic genome folding in three dimensions
Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures…
How DNA and life experiences leave distinct marks on the human immune system
A high-resolution immune cell atlas reveals how inherited DNA and life-long environmental exposures leave separate epigenetic signatures that…
Epigenetic plasticity in germinal center B cells may help explain lymphoma origins
Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
Researchers create the most detailed 3D maps of the human genome
In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators…
iNOME-seq: in vivo simultaneous genome-wide mapping of chromatin accessibility, nucleosome positioning, DNA-binding protein sites, and DNA methylation in Arabidopsis | Genome Biology
Plant lines and growth conditions The plant lines used in this study were derived from A. thaliana wild-type…
MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer
By decoding age gaps across the brain, heart, liver, and more, scientists show that no two organs grow…