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Browsing Tag

Chronic

366 posts
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Berberine improves cognitive function in diabetic encephalopathy mice
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Older adults show high willingness for Alzheimer’s blood tests

  • April 16, 2026
Northwestern University psychologist Andrea Russell sees older adults with early cognitive impairment riddled with anxiety. Some worry a missed word or…
HHealth
Precision nutrition offers new pathways to slow biological aging
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Gut-liver changes drive foodborne infection severity in fatty liver disease

  • April 15, 2026
A research team led by the University of California, Irvine’s Joe C. Wen School of Population & Public…
HHealth
Early B cell response prevents Oropouche virus from reaching the brain
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Aston University bioscientist receives £125,000 to investigate genetic reasons for neurodegeneration

  • April 15, 2026
Aston University bioscientist Dr John Reynolds has won a £125,000 Springboard grant from the Academy of Medical Sciences…
HHealth
Waist-to-height ratio outperforms BMI in predicting hypertension risk
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Waist-to-height ratio outperforms BMI in predicting hypertension risk

  • April 15, 2026
New waist-to-height cut-offs to assess fat mass and obesity predicted the risk of hypertension better than body mass…
HHealth
Study: Divergent inflammatory and neurology-related protein levels in long COVID following primary and breakthrough SARS-CoV-2 infections. Image Credit: vectorfusionart / Shutterstock
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Study finds long COVID leaves a distinct immune signature in the blood

  • April 15, 2026
Blood tests revealed protein patterns tied to long COVID months after infection, while booster shots did not appear…
HHealth
Mother hug and consoling the little boy from nightmare
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A new model to break the cycle of chronic nightmares in children

  • April 14, 2026
A novel framework reveals why nightmares persist in children, and how building confidence and coping skills could help…
HHealth
SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection
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Microneedle nanoparticle platform improves lymphatic imaging with high resolution

  • April 13, 2026
The lymphatic system plays a critical role in pathological conditions such as lymphedema and chronic inflammation to tumor…
HHealth
Healthy lifestyle setup with fresh food, water, and exercise in a park
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Moving more, sitting less, and sleeping well may lower dementia risk

  • April 13, 2026
Data from millions of people reveal that everyday habits, like how much you move, sit, and sleep, could…
HHealth
Study: Tobacco smoke but not e-cigarette vapor induces epithelial barrier disruption, inflammation, and DNA damage in human Calu-3 cells. Image Credit: Antonio Marca / Shutterstock
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Lab study shows cigarette smoke damaged lung cells more than e-cigarette vapor

  • April 13, 2026
A new laboratory study found that cigarette smoke sharply disrupted lung cell defenses, while e-cigarette vapor showed no…
HHealth
Study: Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact. Image Credit: Rudmer Zwerver / Shutterstock
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Rat hepatitis E virus may be a hidden cause of hepatitis in humans

  • April 13, 2026
A growing body of evidence suggests that rat hepatitis E virus is spilling into humans more often than…
HHealth
New method brings hope for personalized treatment of inflammatory bowel disease
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EV-RNAs show promise for IBD diagnosis and treatment

  • April 11, 2026
A research team led by Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, has published a comprehensive…
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