Researchers uncover mechanism by which BRCA2-deficient tumors develop chemoresistance
One of the biggest challenges in cancer treatment is chemoresistance: tumors that initially respond well to chemotherapy become…
Novel 3D chromosome mapping method can reliably reveal hidden structural variants
Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method…
Hypoxia weakens the body’s infection defense by changing genetic material of neutrophils
Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body’s…
Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding
Researchers found that mothers who ate both peanuts and peanut butter during pregnancy had children with distinct DNA…
Frogs help Fred Hutch find the shape of small things
Molecules too few and far between for standard cryo-EM Cryo-EM suspends purified and concentrated molecules in a super…
Ancient DNA uncovers paratyphoid and relapsing fever among Napoleonic troops
Scientists from the Institut Pasteur have genetically analyzed the remains of former soldiers who retreated from Russia in…
Study unravels the genetic shield against winter vomiting disease
Winter vomiting disease is caused by the Norovirus, which is most virulent during the colder half of the…
Unveiling the dual role of HIV integrase in viral replication
The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most…
New gene-editing method can correct many disease-causing mutations in mammalian cells
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
Common test to assess viability of IVF embryos may be flawed
A test deployed in many fertility clinics to assess the viability of embryos for use in IVF is…
Nuclear binding protein identified as key contributor to trisomy 21-related CHDs
Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in…
HMGN1 gene linked to heart problems in people with Down syndrome
Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that…