Degrading mutant KRAS protein induces greater lung cancer regression
KRAS is one of the oncogenes most frequently altered in cancer, mutated in approximately one-third of lung adenocarcinomas.…
Mitochondrial checkpoint enables dendritic cells to activate T lymphocytes against viruses, tumors
A study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has identified a mitochondrial “checkpoint”…
Combination therapy improves response rates for chronic hepatitis B patients
Background and aims The optimal management strategy for adults with immune-tolerant (IT) chronic hepatitis B infection remains undefined.…
New eye drop formulation shows promise for dry eye disease
Researchers at Baylor College of Medicine and Okayama University in Japan have developed and tested in mice a…
Polymer-based immunotherapies enhance tumor targeting and immune activation
Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but typically benefit less…
ChatCPR instructor delivers near-perfect CPR guidance in proof-of-concept study
A new AI-powered CPR instructor achieved near-perfect guideline adherence in simulated and retrospective 911-call testing, suggesting a scalable…
New nanoparticles disable drug resistance to achieve complete tumor elimination
Cancer cells frequently develop the ability to expel anticancer drugs before they can work — a phenomenon called…
Popular GLP-1 drugs significantly reduce major cardiovascular events,
Widely used diabetes and obesity drugs show powerful heart-protective effects in high-risk patients, offering new momentum for their…
A new tool that predicts obesity-related disease risk beyond BMI
A data-driven tool built from nearly 200,000 individuals reveals who is most likely to develop serious obesity-related diseases,…
NIH awards $3.9 million grant to develop a non-opioid pain treatment
The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded…
New cord blood approach boosts survival in blood disease patients
A new way of using umbilical cord blood for treating blood diseases could make the treatment more accessible…
Alzheimer’s monoclonal antibodies fail to deliver meaningful results
Despite successfully removing amyloid plaques from the brain, widely anticipated antibody therapies fail to deliver meaningful cognitive improvements,…