Giant-nucleus cells form the foundation of early-stage cancer
Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells…
Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Researchers find a new genetic vulnerability in acute myeloid leukemia
A study published in Nature Cell Biology reports a new vulnerability in acute myeloid leukemia (AML) that might…
Cell death crosstalk network drives acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) remains one of the deadliest complications of severe infections, sepsis, trauma, and viral…
Evolutionary noncoding RNAs reveal new targets for cancer therapy
In cancer research, one person’s junk is increasingly becoming another person’s treasure. Scientists have now uncovered new evidence…
Iron overload gradually increases neurons’ vulnerability to neurodegeneration
Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer’s and Parkinson’s diseases are the most…
Melatonin improves skin flap survival by reducing ferroptosis
Random-pattern skin flaps are widely used to repair defects caused by trauma, burns, tumor removal, and other injuries…
Study shows how TAF1 regulates ferroptosis in cancer cells
Ferroptosis has become a promising area in cancer research because it may provide a way to target tumor…
Exploiting a new weakness in ‘zombie-like’ cells to treat senescence-associated diseases
A new set of drugs exploit a recently-revealed weakness in ‘zombie-like’ – or senescent – cells that could lead to new treatments for cancer and age-associated diseases. The study from the…
Study reveals lung-brain link between smoking and neurodegeneration
The correlation between smoking and neurodegeneration is well-documented, with one study from 2011 finding heavy smoking in midlife was associated…
Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
Vitamin B2 metabolism helps cancer cells resist ferroptosis
A lack of vitamin B2 makes tumor cells more susceptible to a unique form of cell death. This…