Targeting cyclin-dependent kinases offers new pathways for cancer therapy
Cancer is the second leading cause of death in Germany. In the search for new therapeutic approaches that…
Sprint exercise sends a very different molecular signal through the body
Just minutes of all-out sprint work produced a striking surge in circulating proteins and metabolites, revealing how exercise…
Molecular mapping reveals hidden cellular programs in heart transplant rejection
A new study that explores gene expression during heart transplant rejection marks a step forward for precision medicine…
Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation
Gupta R, Woo K, Yi JA. Epidemiology of end-stage kidney disease. Semin Vasc Surg. 2021;34:71–78. https://doi.org/10.1053/j.semvascsurg.2021.02.010 Article PubMed …
Chinese researchers map epigenetic control of congenital heart defects
The findings have direct implications for clinical practice and future research. For genetic screening, the study provides a…
Five epigenetic clocks reveal shared and distinct signals of aging
A large multi-omics study maps why epigenetic clocks capture different aspects of aging and shows how gene-expression scores…
Study reveals sex-based protein differences across lung cancer types
Biological sex factors into cancer in ways you might not expect. In lung cancer, a form called squamous…
Blood-based gene tests show promise for pancreatic cancer screening
Researchers at Kanazawa University report the blood-based gene expression tests may enable early pancreatic cancer screening and improve…
Mitochondrial DNA mutations link to cardiometabolic parameters in metabolic syndrome
Background and objectives Mitochondrial DNA (mtDNA) variability, especially heteroplasmy, is believed to affect cellular immunobiogenesis, particularly in monocytes…
Integrating gene signatures and multi omics improves liver cancer treatment
Hepatocellular carcinoma (HCC) remains highly fatal due to late diagnosis and scarce early biomarkers. Multi‑omics and liquid biopsy…
Genes follow a random switching principle, yet remain precise on average
Inside the cell nucleus, genes must be turned on and off with precision to regulate biological processes. The…
New bionic skin wound dressing accelerates infected tissue healing
Dressings face a critical limitation: no single product has successfully integrated protective function, wearing comfort, and efficient antibacterial…