Pseudogene lncRNAs regulate cancer stem cell behavior and signaling
Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to…
“It Was Survival Mode”: The Lunar Mission That Nearly Ended in Disaster
Griffin: During entry, there’s what we call a blackout, which is when it gets so hot that you…
Dynamic AI models detect body tipping points to forecast disease before symptoms
The editorial, “Dynamics-driven medical big data mining: dynamic approaches to early disease forecasting and individualized care,” published in…
Vibrio cholerae acquires antiviral defenses through horizontal gene transfer
Like most bacteria, Vibrio cholerae lives under constant attack from viruses. To survive, bacteria equip themselves with antiviral…
New 3D organoid model advances pediatric glioma research and treatment
A three-dimensional experimental system has been developed to study the response to drugs in low-grade glioma, a tumor…
Cola may quickly lower pH inside orthodontic clear aligners and shift oral bacteria within hours
A 24-hour microbiome study suggests that cola can rapidly disturb the aligner-tooth microenvironment, and that removing aligners before…
New strategy exploits specific genetic vulnerability in colorectal cancer patients
Researchers have identified a novel therapeutic approach for colorectal cancer by exploiting a specific genetic vulnerability found in…
Toxic RNA drives progressive heart damage in myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is the most common cause of adult-onset muscular dystrophy, a genetic disorder that…
Researchers uncover a chain of molecular events behind early brain changes in Alzheimer’s
For the millions of people who carry the gene APOE4, the strongest known genetic risk factor for Alzheimer’s…
Study identifies a common hidden genetic cause of neurodevelopmental disorder in children
A major genetic study has uncovered a surprisingly common recessive cause of neurodevelopmental disorder, revealing how hidden changes…
AEGIS tool helps scientists study evolution of aging and lifespan
Why do some species live for only weeks while others survive for centuries? Researchers at the Leibniz Institute…
How could bisphenol A raise depression risk? Study identifies six key molecular targets
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may…