External signals control oncolytic bacteria for precise cancer therapy delivery
Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune…
Virus shells use asymmetry to control RNA release and infection
Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Study provides new insights into brain signaling during sleep and wakefulness
An international team led by the University of Michigan has introduced new methods that reveal which regions of…
Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells
By engineering nanomaterials that boost mitochondrial biogenesis, researchers show how stem cells can become powerful “mitochondrial biofactories,” offering…
AI-driven method uncovers genetic interactions that fuel cancer progression
University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel…
Timing of genetic mutation dictates childhood leukemia aggressiveness
A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with…
Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia
The first study assessing the real-world commercial roll-out of gene therapies for sickle cell disease and beta thalassemia…
Urine cfDNA patterns emerge as a promising tool for diagnosing bladder cancer
Researchers have discovered that analyzing specific patterns of cell-free DNA (cfDNA) fragmentation in a simple urine sample can…
Retinal organoids provide a powerful tool to diagnose and study Leber congenital amaurosis
Leber Congenital Amaurosis (LCA) is an inherited retinal disease leading to severe vision impairment from early infancy, affecting…
AI model popEVE: Prioritizing genetic variants effectively
By combining deep evolutionary signals with human population data, the popEVE model provides a novel approach to identifying…
Gene variant linked to higher risk of chronic rejection after lung transplant
About one third of lung transplant recipients have a genetic variant that makes them more likely to develop…