New gene-editing method can correct many disease-causing mutations in mammalian cells
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
Nuclear binding protein identified as key contributor to trisomy 21-related CHDs
Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in…
HMGN1 gene linked to heart problems in people with Down syndrome
Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that…
Genetic inflammatory signature defines depression subtypes and treatment response
Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that…
Researchers develop a novel approach to monitor CD8⁺ T cell activity over time
The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key…
Epigenetic editing enables safer and more effective T cell therapies
Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that…
Women with isolated REM sleep behavior disorder show lesser brain atrophy than men
A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson’s disease…
Genetic and inflammatory factors amplify the link between earlier menopause and cognitive risk
Women are significantly more likely than men to develop Alzheimer’s disease. Earlier age at menopause is associated with…
Lead Exposure May Have Influenced Evolution of Human Brain, Behavior, and Development of Language
Several hominids — Australopithecus africanus, Paranthropus robustus, early Homo sp., Gigantopithecus blacki, Pongo sp., Papio sp., Homo neanderthalensis,…
MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer
By decoding age gaps across the brain, heart, liver, and more, scientists show that no two organs grow…
New insights reveal persistent genome structure during cell division
Before cells can divide, they first need to replicate all of their chromosomes, so that each of the…
Cancer hijacks embryonic gene editors to fuel growth
Cancer cells are known to reawaken embryonic genes to grow. A new study reveals the disease also hijacks…