AI-driven method uncovers genetic interactions that fuel cancer progression
University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel…
Timing of genetic mutation dictates childhood leukemia aggressiveness
A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with…
Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia
The first study assessing the real-world commercial roll-out of gene therapies for sickle cell disease and beta thalassemia…
Urine cfDNA patterns emerge as a promising tool for diagnosing bladder cancer
Researchers have discovered that analyzing specific patterns of cell-free DNA (cfDNA) fragmentation in a simple urine sample can…
Retinal organoids provide a powerful tool to diagnose and study Leber congenital amaurosis
Leber Congenital Amaurosis (LCA) is an inherited retinal disease leading to severe vision impairment from early infancy, affecting…
AI model popEVE: Prioritizing genetic variants effectively
By combining deep evolutionary signals with human population data, the popEVE model provides a novel approach to identifying…
Gene variant linked to higher risk of chronic rejection after lung transplant
About one third of lung transplant recipients have a genetic variant that makes them more likely to develop…
Discovery of smOOP RNAs reveals hidden rules of cellular phase separation
Inside cells, RNAs and proteins form tiny, liquid-like droplets called biomolecular condensates. These droplets are essential for organizing…
Blocking a ‘gerozyme’ reverses cartilage loss in mice
An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in…
Breakthrough platform reveals the choreography of mammalian transcription
Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads…
Researchers discover new mutation hotspot in the human genome
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA…
New insights into ribosome collisions and stress response
LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell. Ribosomes, the protein factories of…