Synthetic lethality in cancer drug discovery: challenges and opportunities
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches…
Neglecting land–atmosphere feedbacks overestimates climate-driven increases in evapotranspiration
Fischer, E. M. & Knutti, R. Anthropogenic contribution to global occurrence of heavy-precipitation and high-temperature extremes. Nat. Clim.…
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Study design and data sources The data used in this study are collected and used in line with…
Analog in-memory computing attention mechanism for fast and energy-efficient large language models
Hardware-based neural network simulations We implement the sliding window attention by masking the elements of S outside the…
Twenty years of progress in human exercise metabolism research
Hawley, J. A., Hargreaves, M., Joyner, M. J. & Zierath, J. R. Integrative biology of exercise. Cell 159,…
A genome-wide association analysis reveals new pathogenic pathways in gout
Kuo, C. F. et al. Global epidemiology of gout: prevalence, incidence and risk factors. Nat. Rev. Rheumatol. 11,…
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Ethics statement This study included de-identified data from participants who had consented to the use of their anonymized…
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes
An overview of the SINGER algorithm SINGER takes in phased WGS data and samples ARGs iteratively by adding…
Highly protected areas buffer against aridity thresholds in global drylands
Cherlet, M. et al. World Atlas of Desertification (Publication Office of the European Union, 2018). Davies, J. et…
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Mental well-being and work capacity: a cross-sectional study in a sample of the Swedish working population | BMC Public Health
An epidemiological cross-sectional study design was used, and data were collected from autumn 2021 until summer 2022 through…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Article …