Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions
Ethics Our study complies with all relevant ethical regulations and was approved by the institutional review boards at…
Scientists find link between genes and ME/chronic fatigue syndrome | ME / Chronic fatigue syndrome
Scientists have found the first robust evidence that people’s genes affect their chances of developing myalgic encephalomyelitis or…
New Method Calculates Rate of Gene Expression in a Cell
Essentially all cells in an organism’s body have the same genetic blueprint, or genome, but the set of…
Genetic Light Switches Revolutionize Disease Control
Imagine being able to flip a light switch to control disease pathways inside a living cell. A team…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Parent-of-origin effects on complex traits in up to 236,781 individuals
UK Biobank genotype processing We used the UK Biobank Axiom Array data provided in PLINK format39 and converted…
Wider access to DNA screening urged, to tackle diseases such as breast, ovarian and bowel cancer
“It was a bit of a shock. But they went through everything in a lot of detail, and…
New Open-Source Data Platform Launched to Advance Lung Cancer Genetics
In a groundbreaking development poised to accelerate lung cancer research, the 23andMe Research Institute, in collaboration with Troper…
Gene-editing human embryos to prevent disease : Shots
Advances in gene-editing are leading to renewed interest in modifying DNA in human embryos. VICTOR HABBICK VISIONS/Science Photo…
The Family Fallout of DNA Surprises
Sigmund Freud, in “Family Romances,” writes that all of us, once we realize as children the uncertainty of…