New method reveals how human cells initiate DNA replication
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process…
Study reveals ATM kinase as the key driver of replicative senescence
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the…
Researchers discover new mutation hotspot in the human genome
Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA…
Genetic signals reveal why erectile dysfunction develops and who is most at risk
New genomic evidence unmasks the biological pathways driving erectile dysfunction, linking cardiometabolic disease and addiction traits to ED…
Discovery of sequence-driven DNA methylation offers new path for epigenetic engineering
All the cells in an organism have the exact same genetic sequence. What differs across cell types is…
Scientists uncover genetic components linked to bone density in young people
Researchers at Children’s Hospital of Philadelphia (CHOP) revealed important genetic components that affect bone density in children and…
Scientists map the genetic control system behind FOXP3 in immune cells
The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer,…
Global survey reveals struggles of young mothers living with advanced breast cancer
Nearly half of all women aged younger than 40 who live with advanced breast cancer have children under…
Novel 3D chromosome mapping method can reliably reveal hidden structural variants
Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method…
Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease
A global research team has pinpointed the enzyme fueling hydrogen production in healthy guts and shown how its…
Genetic inflammatory signature defines depression subtypes and treatment response
Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that…
Exercise can mitigate depression-like behaviors induced by high-fat, high-sugar diets
Researchers led by Professor Yvonne Nolan at University College Cork have identified specific metabolic pathways through which exercise…