Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Review outlines effective approaches to reduce recurrent hepatic encephalopathy
Hepatic encephalopathy (HE) is a neurologic complication of advanced liver disease, causing impaired functioning, reduced quality of life…
Microbial metabolites could help improve functional cure rates for hepatitis B
Chronic hepatitis B (CHB) remains a major global challenge. Current therapies suppress HBV but rarely achieve functional cure…
Singing therapy provides effective relief for supragastric belching patients
A new randomized clinical trial suggests that singing therapy may provide a more effective and engaging treatment option than standard…
Study sheds light on why red meat may worsen inflammatory bowel disease
New research sheds light on why red meat may worsen inflammatory bowel disease (IBD) – and how other protein sources could help protect the gut. In…
Chronic liver disease threatens millions across Europe, report finds
Europe is facing a growing chronic liver disease threat, according to a new Series published today in The…
Combination therapy improves response rates for chronic hepatitis B patients
Background and aims The optimal management strategy for adults with immune-tolerant (IT) chronic hepatitis B infection remains undefined.…
Targeting a key protein reduces injury in steatotic liver transplantation
Background and aims Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely…
Colbopasvir plus sofosbuvir achieves high cure rates in chronic hepatitis C
Abstract In this real‑world multicenter study (Wenzhou, China), 113 chronic hepatitis C patients received colbopasvir (60 mg) +…
Study identifies key risk factors driving MASLD across populations
Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. The…
Molecular test shows high sensitivity in detecting bile duct cancer
When patients develop a narrowing or blockage in the bile ducts – the tubes connecting the liver, gallbladder…
Dysplasia grade predicts colorectal cancer risk in people with IBD
People with inflammatory bowel disease (IBD) and precancerous colorectal lesions are much more likely to develop colorectal cancer,…