Uli-epic: profiling RNA modifications from ultra-low input samples | Genome Biology
McCown PJ, Ruszkowska A, Kunkler CN, Breger K, Hulewicz JP, Wang MC, et al. Naturally occurring modified ribonucleosides.…
The global burden of motor neuron disease: a systematic and additional analysis of global burden disease study 2021 | Orphanet Journal of Rare Diseases
Data source The GBD 2021 employed the most up-to-date epidemiological data, complemented by refined and standardized methodologies, to…
Clinical manifestations and treatment of peripheral odontogenic keratocysts: two cases and a literature review | Orphanet Journal of Rare Diseases
POKC is a particular type of OKC. Investigating the origin of POKC is critical, and its origin may…
Unlocking the regulatory code of RNA: launching the Human RNome Project | Genome Biology
The Human RNome Project aims to ensure consistent and reproducible outcomes in RNA sequencing and modification studies by…
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…
iNOME-seq: in vivo simultaneous genome-wide mapping of chromatin accessibility, nucleosome positioning, DNA-binding protein sites, and DNA methylation in Arabidopsis | Genome Biology
Plant lines and growth conditions The plant lines used in this study were derived from A. thaliana wild-type…
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
AI Human Genetics Platform Mystra Debuts for Drug Discovery, Validation
Officially unveiled at the American Society of Human Genetics (ASHG) 2025 meeting held in Boston, Genomics has launched…
Redefining cellular reprogramming with advanced genomic technologies
Briggs, R. & King, T. J. Transplantation of living nuclei from blastula cells into enucleated Frogs’ eggs. Proc.…
Characterization of induced cohesin loop extrusion trajectories in living cells
Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers
Genetic ancestry is a quantitative measure of inherited genetic variation and correlates with human migration patterns1. It contributes…
SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations | Genome Biology
Model residuals of linear regression and logistic regression Linear regression and logistic regression are regular models to fit…