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Browsing Tag

Inflammasome

8 posts
HHealth
Johns Hopkins researchers identify human resistin as a key driver of inflammation
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Johns Hopkins researchers identify human resistin as a key driver of inflammation

  • September 9, 2026
Researchers at Johns Hopkins Medicine have uncovered a critical biological mechanism that helps explain how inflammation is triggered…
HHealth
A common dietary nutrient feeds a gut pathway linked to atrial fibrillation
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A common dietary nutrient feeds a gut pathway linked to atrial fibrillation

  • July 28, 2026
A 5,090-person cohort and complementary mouse experiments trace how a diet-linked microbial pathway could reshape atrial structure, electrical…
MMedication
Study: Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP. Image Credit: pimpampix / Shutterstock
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Statins may trigger muscle side effects by activating inflammatory danger signals

  • June 25, 2026
New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
HHealth
STING is a key driver of Japanese encephalitis virus induced inflammatory response
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STING is a key driver of Japanese encephalitis virus induced inflammatory response

  • May 30, 2026
Interferon (IFN) and inflammation are the key early defence mechanisms that combat pathogen infection. The cytosolic DNA sensor…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Targeting a key protein reduces injury in steatotic liver transplantation

  • May 22, 2026
Background and aims Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
uPAR and its associated proteins induce multiorgan injury. Dysregulation of innate immunity caused by various physiological challenges, such as diabetes, hypertension, viral and bacterial infections, or smoking, leads to elevated suPAR levels and/or production of the D2D3 protein. Models illustrate the mechanisms through which these proteins cause injury to the kidney (A), pancreas (B), and cardiovascular system (C).
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A single immune protein may help explain why kidney and heart disease often develop together

  • January 7, 2026
A growing body of human, genetic, and experimental evidence suggests that suPAR may not only signal disease risk…
HHealth
Cancer cells found to use ketones as alternate fuel for growth
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New NIH grants fuel research in oral cancer treatment and pain relief

  • November 8, 2025
Researchers at the School of Dentistry at UT Health San Antonio, the academic health center of The University…
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