Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice
A mouse study traces how immune cells activated in the intestine migrate to the dura and persist at…
Scientists traced a hidden immune route that may worsen tau-linked brain damage
Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…
Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration
Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the…
Probiotics may help protect against sarcopenia in older adults
Researchers used three approaches to study whether probiotics could help prevent sarcopenia (age-related loss of muscle mass, strength…
Emerging non-endocytic transmembrane delivery strategies for precision medicine
Conventional endocytosis-mediated delivery is limited by poor endosomal escape efficiency, making intracellular delivery of therapeutic biomacromolecules a long-standing…
Study uncovers mechanism that regulates how the body uses stored fat to produce energy
An international study by scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and the University…
Scientists visualize a key cell protein regulating inflammatory disease pathways
University of Cincinnati structural biologists are the first in the world to visualize a key cell protein as part…
NIH researchers discover how weight-loss drugs alter brain cells
A team of researchers at the National Institutes of Health (NIH) have unveiled new details about the events…
NIH awards $3.9 million grant to develop a non-opioid pain treatment
The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded…
Alzheimer’s monoclonal antibodies fail to deliver meaningful results
Despite successfully removing amyloid plaques from the brain, widely anticipated antibody therapies fail to deliver meaningful cognitive improvements,…
CIPHER-seq technology reveals how immune cells communicate during treatment
A new single-cell technology is giving scientists their clearest view yet of immune cell behavior-capturing not just genetic…
SonoPIN technology boosts intracellular delivery of large cancer drugs
Engineers at Duke University have demonstrated a technique that uses microbubbles and ultrasound to help relatively large cancer…