Cryo-EM reveals NPFFR1 activation and guides novel ligand design
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1…
New findings show why the human intestine uniquely presents gluten to T cells
New evidence shows that human M cells act as fully fledged antigen-presenting cells, processing and presenting gluten peptides…
Immune cell dysregulation and inflammatory mediators shape epilepsy risk
Background and objectives Emerging evidence implicates immune dysregulation and neuroinflammation in the pathogenesis of epilepsy, yet the causal…
Integrating physicochemical laws into future AI models for better drug design
Proteins play a key role not only in the body, but also in medicine: they either serve as…
New fluorescent molecule could be used to generate clearer images of tumors
MIT chemists have designed a new type of fluorescent molecule that they hope could be used for applications…