Biliary epithelial cells found to actively prevent liver fibrosis development
Many liver diseases share a common characteristic: fibrosis, that is, the progressive accumulation of scarring in the liver…
Study identifies key risk factors driving MASLD across populations
Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. The…
Immune cell interactions drive liver inflammation and fibrosis
When the liver is injured – for example, due to bile accumulation – immune cells become activated. In…
Donor-derived dendritic cells teach the immune system to accept new livers
UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant…
A spatial atlas of the healthy human liver from live donors
Experimental methodsHuman sample preparation Human samples and clinical data were obtained from patients undergoing either hepatectomy surgery due…
Gut-liver changes drive foodborne infection severity in fatty liver disease
A research team led by the University of California, Irvine’s Joe C. Wen School of Population & Public…
Rat hepatitis E virus may be a hidden cause of hepatitis in humans
A growing body of evidence suggests that rat hepatitis E virus is spilling into humans more often than…
EV-RNAs show promise for IBD diagnosis and treatment
A research team led by Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, has published a comprehensive…
Study reveals pearling mechanism behind mitochondrial DNA spacing
Mitochondria are often described as the cell’s power plants, because they generate energy. To help them achieve this,…
Higher sugar intake raises gallstone risk in adults, study finds
Researchers analyzing recent NHANES data found that adults with higher total sugar intake had greater odds of gallstones,…
Ultrasound advances offer noninvasive assessment of portal hypertension severity
Portal hypertension (PH), a serious complication of liver cirrhosis, is defined as a pressure gradient > 5 mmHg…
Molecular test shows high sensitivity in detecting bile duct cancer
When patients develop a narrowing or blockage in the bile ducts – the tubes connecting the liver, gallbladder…