New atlas of brain lysosomes sheds light on neurodegenerative disorders
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…
Changes in brain fats play a key role in Alzheimer’s development and progression
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as “lipoid…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
Lysosomal activity in worms linked to transgenerational extension of lifespan
In the Wang Lab, it’s not unusual for worms to live for a long time. HHMI Janelia Research…
Lysosomal acidity fine-tunes reactive species production in macrophages
Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis.…