Aging brains struggle to recycle synaptic proteins
As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …
Regulating microglial phagocytosis through immunotherapy could slow Parkinson’s disease progression
By analyzing tissue from patients with Parkinson’s disease, and animal and cellular models of the disease, a research…
New atlas of brain lysosomes sheds light on neurodegenerative disorders
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…
Study shows DHPS enzyme controls macrophage maturation across multiple organs
A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns…
Study reveals how ketogenic diet protects against epilepsy seizures
University of Virginia School of Medicine researchers have revealed how the popular, low-carb ketogenic diet protects against epilepsy…
Single-cell analysis reveals gene disruptions in early-onset Alzheimer’s brain regions
A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell…
Brain immune cells drive persistent negative emotions after repeated binge drinking
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying…
Changes in brain fats play a key role in Alzheimer’s development and progression
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as “lipoid…
Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory
By flipping a single genetic switch from APOE4 to APOE2 in adult mice, researchers reversed key Alzheimer’s-like changes…
Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis
New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain,…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…