Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of…
New mechanism behind potentially fatal type of epilepsy identified
A team led by the UAB Institut de Neurociències (INc-UAB) has for the first time identified the mechanism…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
New gene-editing method can correct many disease-causing mutations in mammalian cells
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
Second round of exercise boosts muscle growth in mice
New research offers potential good news for those who’ve lapsed at the gym. The study found that mice…
Scientists “Improve on Mother Nature” To Create Powerful Cancer-Killing Molecule
Researchers discovered that bacteria inside tumors can create a molecule that makes chemotherapy more powerful. This surprising microbial…
Antidepressant fluoxetine alters brain energy use and boosts neural plasticity
A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it…
Peroxisomes identified as alternative heat producers in brown fat
Researchers at Washington University School of Medicine in St. Louis have identified a novel way brown fat –…
Scientists Find a Way to “Bulletproof” T Cells Against Cancer
Researchers at the University of Pittsburgh have discovered that the harsh environment inside tumors, characterized by low oxygen…
Female-specific mechanism enhances heat production in brown fat
Higher activity of PGC-1α enables brown fat cells in females to thermogenic activity and energy expenditure compared to…
New method reveals how mitochondrial DNA mutations influence cancer growth
Mitochondria act as energy factories in cells and have their own, separate DNA. Mutations to mitochondrial DNA (mtDNA)…
Rare ABCA7 gene variants linked to Alzheimer’s risk
A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to…