Targeting protein fragment may improve Huntington disease treatments
Treatments that target a fragment of the mutant protein that causes Huntington’s disease might be more effective than…
Key gene mutation disrupts the brain’s ability to update beliefs in schizophrenia patients
One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead patients…
Gene mutation that aids high-altitude survival could repair myelin sheath damage
A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing…
AI trained on 9 trillion DNA letters predicts harmful mutations and designs new genomes
Trained on genomic data spanning the tree of life, Evo 2 reveals how artificial intelligence can decode the…
Novel lipid bubble delivery shows promise for ALS treatment
A researcher at the University of Missouri has made a promising breakthrough in the quest to help people…
MULTI-evolve accelerates protein engineering with machine learning
The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has…
Antibody feedback reshapes B cell selection during immune response
 A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together…
Study elucidates key steps in the ubiquitin tagging of mutated huntingtin protein
Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future…
New diagnostic framework addresses challenges of rapidly-mutating RNA viruses
The rapid evolutionary dynamics of RNA viruses, driven by high mutation rates and the consequent formation of complex…
HIV can develop resistance to lenacapavir, but at a cost to the virus
 Since its first approval in 2022, Gilead Sciences’ lenacapavir—a twice-yearly injectable—has come to be a potential game…
Using AI to understand the age of disease onset in Huntington’s patients
A team from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences at the University…
Single-cell technique maps pre-malignant gene mutations in solid tissues
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the…