FDA-approved drug fedratinib enhances communication between cellular organelles
Cells behave like cities and organelles carry out infrastructural roles: Mitochondria are powerhouses, the endoplasmic reticulum serves as…
CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder
Ayrignac X, Carra-Dalliere C, Codjia P, Mouzat K, Castelnovo G, Ellie E, et al. Evaluation of CSF1R-related adult…
Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
Knopman, D. S. et al. Alzheimer disease. Nat. Rev. Dis. Primers 7, 33 (2021). Article PubMed PubMed Central …
Physical Activity and Early Rising Linked to Lower ALS Risk
Summary: Being an “early bird” and maintaining a physically active lifestyle may significantly reduce the risk of developing…
Scientists uncover nanoplastics in brain tissue and question their role in neurological disease
Scientists are detecting nanoplastics in human brain tissue and exploring how these particles may influence the risk of…
New spatial omics platform advances biomedical research in Spain
Spatial omics is a new generation of technologies that allow scientists to study cells in their original location…
Aging brains struggle to recycle synaptic proteins
As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …
Blood gene signals reveal Parkinson’s risk years before diagnosis
Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of…
Research uncovers why certain brain cells are more resilient to tau protein buildup
New research by UCLA Health and UC San Francisco has uncovered why certain brain cells are more resilient…
New atlas of brain lysosomes sheds light on neurodegenerative disorders
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…
Olive oil type matters for cognition and gut health in older adults
A large cohort study suggests that not all olive oils are equal, with virgin olive oil showing favorable…
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…