A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Study populations The China Health Aging Investigation (CHAI), as a project of the International Consortium of Digital Twin…
Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex
Ethics approval and consent to participate All methods were performed in accordance with the relevant guidelines and regulations.…
Entering the era of precision medicine to treat amyotrophic lateral sclerosis | Molecular Neurodegeneration
Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the…
Re-examining the association between region-specific pain recurrence and muscle force strategies in patients with patellofemoral pain via OpenSim and artificial intelligence: a prospective cohort study toward targeted rehabilitation | Journal of NeuroEngineering and Rehabilitation
In this study, we developed and evaluated an artificial intelligence (machine learning) model to elucidate the muscle force-production…
Speech digital biomarker combined with fluid biomarkers predict cognitive impairment through machine learning | Alzheimer’s Research & Therapy
Demographics, clinical characteristics, core AD fluid, digital and imaging biomarkers among groups A total of 1223 participants were…
Genetic testing of common and rare variants in dementia patients from a memory clinic | Alzheimer’s Research & Therapy
2023 Alzheimer’s disease facts and figures. Alzheimers Dement 19, 1598–1695 (2023). Campion D, et al. Early-onset autosomal dominant…
Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration | Molecular Neurodegeneration
Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT. The epidemiology of alzheimer’s disease modifiable…
Differentiating post-stroke patients from healthy individuals via vision-based skeleton-optical fusion | Journal of NeuroEngineering and Rehabilitation
Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN,…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Regional tau PET patterns predict prospective domain-specific cognitive decline in early symptomatic Alzheimer’s disease | Alzheimer’s Research & Therapy
Our study corroborates the prognostic value of tau-PET regional distribution on cognitive decline in several domains, in a…
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
Enhanced episodic memory and LTP-like plasticity in subjective cognitive decline following 10-Hz repetitive transcranial magnetic stimulation | Journal of NeuroEngineering and Rehabilitation
Yin X, Xie Q, Huang L, Liu L, Armstrong E, Zhen M, et al. Assessment of the psychological…