Pathology

Nicotinic acid starvation sensitizes nicotinate phosphoribosyltransferase-expressing tumors to nicotinamide phosphoribosyltransferase inhibition

October 22, 2026

Nicotinamide adenine dinucleotide (NAD+) biosynthesis underlies many aspects of carcinogenesis. Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), which drives NAD+…

HHealth

A study links a blood protein to memory and brain changes in Down syndrome

October 12, 2026

A study combining blood samples, memory assessments, and brain scans examines whether a protein found at nerve cell…

BBusiness

SARS-CoV-2 seeds IAPP aggregation and β-cell failure

October 9, 2026

Aged infection is associated with extensive IAPP amyloid deposition and insulin loss in primate islets In our previous…

SScience

Review: Gut Microbiome-Mediated Neuroprotective Effect of the Mediterranean Diet: A Narrative Review of Cognitive Aging, Alzheimer’s Disease, and Parkinson’s Disease. Image Credit: LipeBorges_Foto / Shutterstock

September 28, 2026

From microbial metabolites to inflammation and the blood-brain barrier, researchers trace how Mediterranean eating could influence neurodegeneration, while…

HHealth

Study: Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration. Image Credit: Antonio Marca / Shutterstock

September 7, 2026

Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…

HHealth

Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk

August 24, 2026

From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…

HHealth

Berberine improves cognitive function in diabetic encephalopathy mice

August 21, 2026

A review and opinion piece published in The Lancet and led by UCL (University College London) and UCLH…

HHealth

Early B cell response prevents Oropouche virus from reaching the brain

August 6, 2026

With the support of National Institutes of Health funding, Johns Hopkins Medicine investigators, led by pathologist Aaron W.…

HHealth

Study analyzes alterations in the cerebral cortex in people with psychosis

August 4, 2026

Hallucinations and delusions that appear for the first time in midlife or later are often treated as psychiatric…

HHealth

Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

August 3, 2026

Lung infections are a constant risk for people living with cystic fibrosis (CF), a life-threatening genetic disorder which…

HHealth

Study: Nanoscopic tau aggregates in Parkinson’s disease. Image Credit: peterschreiber.media / Shutterstock

July 29, 2026

By examining six brain regions at single-molecule resolution, researchers identified a layer of tau pathology that conventional tissue…

MMedication

Common wearable devices could remotely monitor pregnancy-related health changes

July 21, 2026

A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes…

Nicotinic acid starvation sensitizes nicotinate phosphoribosyltransferase-expressing tumors to nicotinamide phosphoribosyltransferase inhibition

A study links a blood protein to memory and brain changes in Down syndrome

SARS-CoV-2 seeds IAPP aggregation and β-cell failure

Could the Mediterranean diet protect the brain through the gut?

Scientists traced a hidden immune route that may worsen tau-linked brain damage

Disrupted brain-immune signaling may help drive neurodegeneration

Lancet review examines possible amyloid-beta transmission through blood transfusions

Nerve-blocking therapy improves growth plate repair in injured bones

Study connects late-life psychosis to abnormal tau protein buildup

Using DNA sequencing for accurate identification of microbial infections in cystic fibrosis patients

A closer look at Parkinson’s brains finds tau where standard tests saw little

Prenatal use of certain medications can harm developing fetal brain