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Browsing Tag

Pathology

80 posts
HHealth
Study: Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration. Image Credit: Antonio Marca / Shutterstock
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Scientists traced a hidden immune route that may worsen tau-linked brain damage

  • September 7, 2026
Researchers traced an immune pathway from brain-draining lymph nodes to tau-affected tissue, revealing how peripheral immune activity may…
HHealth
Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk
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Disrupted brain-immune signaling may help drive neurodegeneration

  • August 24, 2026
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
HHealth
Berberine improves cognitive function in diabetic encephalopathy mice
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Lancet review examines possible amyloid-beta transmission through blood transfusions

  • August 21, 2026
A review and opinion piece published in The Lancet and led by UCL (University College London) and UCLH…
HHealth
Early B cell response prevents Oropouche virus from reaching the brain
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Nerve-blocking therapy improves growth plate repair in injured bones

  • August 6, 2026
With the support of National Institutes of Health funding, Johns Hopkins Medicine investigators, led by pathologist Aaron W.…
HHealth
Study analyzes alterations in the cerebral cortex in people with psychosis
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Study connects late-life psychosis to abnormal tau protein buildup

  • August 4, 2026
Hallucinations and delusions that appear for the first time in midlife or later are often treated as psychiatric…
HHealth
Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis
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Using DNA sequencing for accurate identification of microbial infections in cystic fibrosis patients

  • August 3, 2026
Lung infections are a constant risk for people living with cystic fibrosis (CF), a life-threatening genetic disorder which…
HHealth
Study: Nanoscopic tau aggregates in Parkinson’s disease. Image Credit: peterschreiber.media / Shutterstock
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A closer look at Parkinson’s brains finds tau where standard tests saw little

  • July 29, 2026
By examining six brain regions at single-molecule resolution, researchers identified a layer of tau pathology that conventional tissue…
MMedication
Common wearable devices could remotely monitor pregnancy-related health changes
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Prenatal use of certain medications can harm developing fetal brain

  • July 21, 2026
A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes…
HHealth
Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects
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New tumor organoids strengthen precision oncology research

  • July 21, 2026
Significant advances have been made in the development of patient-derived tumor “organoids” for preclinical research, in two new…
HHealth
Researchers identify new molecular switch involved in programmed cell death
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Combination treatment strategy uses cells’ waste removal functions to dismantle multiple myeloma

  • July 14, 2026
New research out of VCU Massey Comprehensive Cancer Center provides promising evidence for an innovative combination treatment strategy…
HHealth
Research examines oral health benefits of toothbrush choice and brushing duration
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Study compares different light therapies for treating Alzheimer’s disease

  • July 6, 2026
“We wanted to compare the two most common tPBM paradigms head‑to‑head in a well‑established AD mouse model,” explains…
HHealth
CRISPR-based tongue swab test shows promise for tuberculosis detection
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BCG vaccine may remodel the human brain’s immune environment

  • July 6, 2026
New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine – which is…
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